Frequent productive cough: Symptom burden and future exacerbation risk among patients with asthma and/or COPD in the NOVELTY study. (August 2022)

• Record Type: Journal Article
• Authors: Hughes, Rod; Rapsomaniki, Eleni; Janson, Christer; Keen, Christina; Make, Barry J.; Burgel, Pierre-Régis; Tomaszewski, Erin L.; Müllerová, Hana; Reddel, Helen K.; Benhabib, Gabriel; Ruiz, Xavier Bocca; Olmo, Ricardo del; Lisanti, Raul Eduardo; Marino, Gustavo; Mattarucco, Walter; Nogueira, Juan; Parody, Maria; Pascale, Pablo; Rodriguez, Pablo; Silva, Damian; Svetliza, Graciela; Victorio, Carlos F.; Rolon, Roxana Willigs; Yañez, Anahi; Baines, Stuart; Bowler, Simon; Bremner, Peter; Bull, Sheetal; Carroll, Patrick; Chaalan, Mariam; Farah, Claude; Hammerschlag, Gary; Hancock, Kerry; Harrington, Zinta; Katsoulotos, Gregory; Kim, Joshua; Langton, David; Lee, Donald; Peters, Matthew; Prassad, Lakshman; Reddel, Helen; Sajkov, Dimitar; Santiago, Francis; Simpson, Frederick Graham; Tai, Sze; Thomas, Paul; Wark, Peter; Delfini Cançado, José Eduardo; Cunha, Thúlio; Lima, Marina; Cardoso, Alexandre Pinto; Rabahi, Marcelo; Anees, Syed; Bertley, John; Bell, Alan; Cheema, Amarjit; Chouinard, Guy; Csanadi, Michael; Dhar, Anil; Dhillon, Ripple; FitzGerald, J. Mark; Kanawaty, David; Kelly, Allan; Killorn, William; Landry, Daniel; Luton, Robert; Mandhane, Piushkumar; McIvor, Andrew; Pek, Bonavuth; Petrella, Robert; Stollery, Daniel; Chen, Meihua; Chen, Yan; Gu, Wei; Christopher Hui, Kim Ming; Li, Manxiang; Li, Shiyue; Lijun, Ma; Qin, Guangyue; Song, Weidong; Tan, Wei; Tang, Yijun; Wang, Chen; Wang, Tan; Wen, Fuqiang; Wu, Feng; Xiang, PingChao; Xiao, Zuke; Xiong, Shengdao; Yang, Jinghua; Yang, Jingping; Zhang, Caiqing; Zhang, Min; Zhang, Ping; Zhang, Wei; Zheng, Xiaohe; Zhu, Dan; Grimaldos, Fabio Bolivar; Arboleda, Alejandra Cañas; Bueno, Carlos Matiz; Molina de Salazar, Dora; Bendstrup, Elisabeth; Hilberg, Ole; Kjellerup, Carsten; Weinreich, Ulla; Bonniaud, Philippe; Brun, Olivier; Burgel, Pierre-Régis; Chouaid, Christos; Couturaud, Francis; de Blic, Jacques; Debieuvre, Didier; Delsart, Dominique; Demaegdt, Axelle; Demoly, Pascal; Deschildre, Antoine; Devouassoux, Gilles; Egron, Carole; Falchero, Lionel; Goupil, François; Kessler, Romain; Le Roux, Pascal; Mabire, Pascal; Mahay, Guillaume; Martinez, Stéphanie; Melloni, Boris; Moreau, Laurent; Raherison, Chantal; Riviere, Emilie; Roux-Claudé, Pauline; Soulier, Michel; Vignal, Guillaume; Yaici, Azzedine; Aries, Sven Philip; Bals, Robert; Beck, Ekkehard; Deimling, Andreas; Feimer, Jan; Grimm-Sachs, Vera; Groth, Gesine; Herth, Felix; Hoheisel, Gerhard; Kanniess, Frank; Lienert, Thomas; Mronga, Silke; Reinhardt, Jörg; Schlenska, Christian; Stolpe, Christoph; Teber, Ishak; Timmermann, Hartmut; Ulrich, Thomas; Velling, Peter; Wehgartner-Winkler, Sabina; Welling, Juergen; Winkelmann, Ernst-Joachim; Barbetta, Carlo; Braido, Fulvio; Cardaci, Vittorio; Clini, Enrico Maria; Costantino, Maria Teresa; Cuttitta, Giuseppina; di Gioacchino, Mario; Fois, Alessandro; Foschino-Barbaro, Maria Pia; Gammeri, Enrico; Inchingolo, Riccardo; Lavorini, Federico; Molino, Antonio; Nucera, Eleonora; Papi, Alberto; Patella, Vincenzo; Pesci, Alberto; Ricciardolo, Fabio; Rogliani, Paola; Sarzani, Riccardo; Vancheri, Carlo; Vincenti, Rigoletta; Endo, Takeo; Fujita, Masaki; Hara, Yu; Horiguchi, Takahiko; Hosoi, Keita; Ide, Yumiko; Inomata, Minehiko; Inoue, Hiromasa; Inoue, Koji; Inoue, Sumito; Kato, Motokazu; Kawasaki, Masayuki; Kawayama, Tomotaka; Kita, Toshiyuki; Kobayashi, Kanako; Koto, Hiroshi; Nishi, Koichi; Saito, Junpei; Shimizu, Yasuo; Shirai, Toshihiro; Sugihara, Naruhiko; Takahashi, Ken-ichi; Tashimo, Hiroyuki; Tomii, Keisuke; Yamada, Takashi; Yanai, Masaru; Javier, Ruth Cerino; Peregrina, Alfredo Domínguez; Corzo, Marco Fernández; Gonzalez, Efraín Montano; Ramírez-Venegas, Alejandra; Rendon, Adrian; Boersma, Willem; Djamin, R.S.; Eijsvogel, Michiel; Franssen, Frits; Goosens, Martijn; Graat-Verboom, Lidwien; Veen, Johannes in 't; Janssen, Rob; Kuppens, Kim; van den Berge, Maarten; van de Ven, Mario; Brunstad, Ole Petter; Einvik, Gunnar; Høines, Kristian Jong; Khusrawi, Alamdar; Oien, Torbjorn; Chang, Yoon-Seok; Cho, Young Joo; Hwang, Yong Il; Kim, Woo Jin; Koh, Young-Il; Lee, Byung-Jae; Lee, Kwan-Ho; Lee, Sang-Pyo; Lee, Yong Chul; Lim, Seong Yong; Min, Kyung Hun; Oh, Yeon-Mok; Park, Choon-Sik; Park, Hae-Sim; Park, Heung-Woo; Rhee, Chin Kook; Yoon, Ho Joo; Yoon, Hyoung-Kyu; García-Navarro, Alvar Agusti; Andújar, Rubén; Anoro, Laura; García, María Buendía; Mozo, Paloma Campo; Campos, Sergio; Maldonado, Francisco Casas; Martínez, Manuel Castilla; Serrano, Carolina Cisneros; Casanova, Lorena Comeche; Corbacho, Dolores; Del Campo Matías, Felix; Echave-Sustaeta, Jose; Corral, Gloria Francisco; Setién, Pedro Gamboa; Clemente, Marta García; Núñez, Ignacio García; Robaina, Jose García; Salmones, Mercedes García; Marín Trigo, Jose Maria; Fernandez, Marta Nuñez; Palomo, Sara Nuñez; Rivera, José Olaguibel; Pérez de Llano, Luis; Bastida, Ana Pueyo; Rañó, Ana; González-Moro, José Rodríguez; Reig, Albert Roger; Garrido, José Velasco; Curiac, Dan; Janson, Christer; Lif-Tiberg, Cornelia; Luts, Anders; Råhlen, Lennart; Rustscheff, Stefan; Adams, Frances; Bradman, Drew; Broughton, Emma; Cosgrove, John; Flood-Page, Patrick; Fuller, Elizabeth; Harrison, Timothy; Hartley, David; Hattotuwa, Keith; Jones, Gareth; Lewis, Keir; McGarvey, Lorcan; Morice, Alyn; Pandya, Preeti; Patel, Manish; Roy, Kay; Sathyamurthy, Ramamurthy; Thiagarajan, Swaminathan; Turner, Alice; Vestbo, Jorgen; Wedzicha, Wisia; Wilkinson, Tom; Wilson, Pete; Al-Asadi, Lo'Ay; Anholm, James; Averill, Frank; Bansal, Sandeep; Baptist, Alan; Campbell, Colin; Campos, Michael A.; Chipps, Bradley; Crook, Gretchen; DeLeon, Samuel; Eid, Alain; Epstein, Ellen; Fritz, Stephen; Harris, Hoadley; Hewitt, Mitzie; Holguin, Fernando; Hudes, Golda; Jackson, Richard; Kaufman, Alan; Kaufman, David; Klapholz, Ari; Krishna, Harshavardhan; Lee, Daria; Lin, Robert; Maselli-Caceres, Diego; Mehta, Vinay; Moy, James N.; Nwokoro, Ugo; Parikh, Purvi; Parikh, Sudhir; Perrino, Frank; Ruhlmann, James; Sassoon, Catherine; Settipane, Russell A.; Sousa, Daniel; Sriram, Peruvemba; Wachs, Richard;
• Is Part Of: Respiratory medicine. Volume 200(2022)
• Publication Date: 2022-08
• Subjects: Frequent productive cough -- Chronic bronchitis -- Chronic mucus hypersecretion -- Obstructive lung diseases -- Patient-reported outcome measures -- Sputum; Chest -- Diseases -- Periodicals; Chest -- Diseases -- Great Britain -- Periodicals; Respiratory organs -- Diseases -- Periodicals; Respiratory Tract Diseases -- Periodicals; Appareil respiratoire -- Maladies -- Périodiques; Thorax -- Maladies -- Périodiques; Appareil respiratoire -- Maladies -- Traitement -- Périodiques; Electronic journals; 616.2
• DOI: 10.1016/j.rmed.2022.106921
• Languages: English
• ISSNs: 0954-6111

Abstract

Abstract: Introduction: Persistent cough with sputum production is an important clinical trait in chronic obstructive pulmonary disease (COPD). We defined "frequent productive cough" based on 2 questions from the St George's Respiratory Questionnaire (SGRQ) and sought to determine its occurrence and associated outcomes in patients with physician-assigned asthma and/or COPD from the NOVELTY study. Methods: Frequent productive cough was defined as cough and sputum production most or several days/week for the past 3 months (scoring ≥3 for both SGRQ questions). Relationships with baseline disease characteristics and exacerbations over 12 months' follow-up were examined using logistic regression. Results: Baseline SGRQ data were available for 7125 patients, of whom 31.3% had frequent productive cough. It was more common in asthma+COPD (38.8%) and COPD (38.1%) than asthma (25.0%), increasing with physician-assessed severity, and in current versus former and never smokers. Patient-reported symptomatic worsening was more common in patients with versus without frequent productive cough. Reduced post-bronchodilator FEV1 (odds ratio [OR] per 10% decrement 1.14 [95% confidence interval 1.11–1.16]) and history of pollutant exposure at home/work (OR 1.50 [1.33–1.69]) were associated with frequent productive cough in all diagnoses. Patients with baseline frequent productive cough were more likely to have ≥1 exacerbation over the subsequent 12 months (OR 1.71 [1.52–1.93]), including exacerbations requiring hospital admission and those treated with oral corticosteroids. Conclusions: Frequent productive cough represents an important indicator of adverse clinical outcomes across asthma and/or COPD. Research into the underlying pathologic mechanisms is required to support targeted therapy development. Clinicaltrials.gov: NCT02760329. Highlights: Frequent productive cough was present across physician-assigned asthma and/or COPD. Prevalence of this clinical trait increased with higher physician-assessed severity. The trait was associated with reduced FEV1 and pollutant exposure in all diagnoses. Frequent productive cough was associated with higher risk of greater disease burden.