Versatile signaling mechanisms of inositol pyrophosphates. (October 2022)

• Record Type: Journal Article
• Authors: Nguyen Trung, Minh; Furkert, David; Fiedler, Dorothea
• Is Part Of: Current opinion in chemical biology. Volume 70(2022)
• Publication Date: 2022-10
• Subjects: Cell signaling -- Inositol phosphate -- Inositol pyrophosphate -- IP6K -- PPIP5K -- 5PP-InsP5 -- InsP8 -- Protein ligand interaction -- SPX domain -- Chemical tools -- Protein pyrophosphorylation; Bioorganic chemistry -- Periodicals; Biology -- Periodicals; Biochemistry -- Periodicals; Clinical biochemistry -- Periodicals; Biochemistry -- Periodicals; Chimie bio-organique -- Périodiques; Biologie -- Périodiques; 572.05
• DOI: 10.1016/j.cbpa.2022.102177
• Languages: English
• ISSNs: 1367-5931

Abstract

Abstract: Inositol pyrophosphates (PP-InsPs) constitute a group of highly charged messengers, which regulate central biological processes in health and disease, such as cellular phosphate and general energy homeostasis. Deciphering the molecular mechanisms underlying PP-InsP-mediated signaling remains a challenge due to the unique properties of these molecules, the different modes of action they can access, and a somewhat limited chemical and analytical toolset. Herein, we summarize the most recent mechanistic insights into PP-InsP signaling, which illustrate our progress in connecting mechanism and function of PP-InsPs. Highlights: PP-InsPs are central eukaryotic messengers with diverse modes of action. PP-InsPs interact with specific protein domains, most prominently SPX domains. Recently developed analytical and chemical tools have aided the elucidation of PP-InsP signaling mechanisms.