Inside Cover: Deciphering the Metal Speciation in Low‐Molecular‐Weight Complexes by IMS‐MS: Application to the Detection of Manganese Superoxide Dismutase Mimics in Cell Lysates (Angew. Chem. Int. Ed. 38/2022). Issue 38 (25th July 2022)

• Record Type: Journal Article
• Authors: Zoumpoulaki, Martha; Schanne, Gabrielle; Delsuc, Nicolas; Preud'homme, Hugues; Quévrain, Elodie; Eskenazi, Nicolas; Gazzah, Géraldine; Guillot, Regis; Seksik, Philippe; Vinh, Joelle; Lobinski, Ryszard; Policar, Clotilde
• Is Part Of: Angewandte Chemie international edition. Volume 61:Issue 38(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-07-25
• Subjects: Bioinorganic Chemistry -- Intracellular Detection -- Ion Mobility Spectroscopy -- Manganese(II) Superoxide Dismutase Mimics or Mimetics -- Mass Spectrometry; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.202210260
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract : Within the crowded cell environment, Mn‐based superoxide dismutase (SOD) mimics were detected and quantified, with an analogous [ 13 C6 LCo II ] (L=ligand) as a standard, in intricate cell lysates by using ion mobility spectrometry coupled to mass spectrometry (IMS‐MS). In their Research Article (e202203066 ), Clotilde Policar and co‐workers show that IMS is powerful enough to separate complexes of the same ligand bound to different divalent metal cations with similar ionic radii. In timsTOF, ions are pushed by the gas flow, retained electrostatically, and as represented in the picture, the smaller, the slower.