Metabolic syndrome and hidradenitis suppurativa: epidemiological, molecular, and therapeutic aspects. (16th September 2021)

• Record Type: Journal Article
• Authors: Mintoff, Dillon; Benhadou, Farida; Pace, Nikolai P.; Frew, John W.
• Is Part Of: International journal of dermatology. Volume 61:Number 10(2022)
• Page Start: 1175
• Page End: 1186
• Publication Date: 2021-09-16
• Subjects: Dermatology -- Periodicals; 616.5
• DOI: 10.1111/ijd.15910
• Languages: English
• ISSNs: 0011-9059

Abstract

Abstract: Hidradenitis suppurativa (HS) is a chronic, suppurative condition of the pilosebaceous unit. Patients suffering from HS demonstrate a molecular profile in keeping with a state of systemic inflammation and are often found to fit the criteria for a diagnosis of metabolic syndrome (MetS). In this paper, we review the literature with regards to established data on the prevalence of MetS in HS patients and revise the odds ratio of comorbid disease. Furthermore, we attempt to draw parallels between inflammatory pathways in HS and MetS and evaluate how convergences may explain the risk of comorbid disease, necessitating the need for multidisciplinary care.