Differentiation of hemangioblastoma from brain metastasis using MR amide proton transfer imaging. Issue 5 (22nd June 2022)

• Record Type: Journal Article
• Authors: Kamimura, Kiyohisa; Nakajo, Masanori; Gohara, Misaki; Kawaji, Kodai; Bohara, Manisha; Fukukura, Yoshihiko; Uchida, Hiroyuki; Tabata, Kazuhiro; Iwanaga, Takashi; Akamine, Yuta; Keupp, Jochen; Fukami, Tomoaki; Yoshiura, Takashi
• Is Part Of: Journal of neuroimaging. Volume 32:Issue 5(2022)
• Page Start: 920
• Page End: 929
• Publication Date: 2022-06-22
• Subjects: amide proton transfer imaging -- brain metastasis -- diffusion‐weighted imaging -- hemangioblastoma -- MRI -- perfusion‐weighted imaging; Diagnostic imaging -- Periodicals; Nervous system -- Diseases -- Diagnosis -- Periodicals; Imagerie pour le diagnostic -- Périodiques; Système nerveux -- Maladies -- Diagnostic -- Périodiques; Imagerie médicale; Neuroimagerie; Neurologie; Système nerveux; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.804754
• DOI: 10.1111/jon.13019
• Languages: English
• ISSNs: 1051-2284

Abstract

Abstract: Background and Purpose: Differentiation between hemangioblastoma and brain metastasis remains a challenge in neuroradiology using conventional MRI. Amide proton transfer (APT) imaging can provide unique molecular information. This study aimed to evaluate the usefulness of APT imaging in differentiating hemangioblastomas from brain metastases and compare APT imaging with diffusion‐weighted imaging and dynamic susceptibility contrast perfusion‐weighted imaging. Methods: This retrospective study included 11 patients with hemangioblastoma and 20 patients with brain metastases. Region‐of‐interest analyses were employed to obtain the mean, minimum, and maximum values of APT signal intensity, apparent diffusion coefficient (ADC), and relative cerebral blood volume (rCBV), and these indices were compared between hemangioblastomas and brain metastases using the unpaired t ‐test and Mann‐Whitney U test. Their diagnostic performances were evaluated using receiver operating characteristic (ROC) analysis and area under the ROC curve (AUC). AUCs were compared using DeLong's method. Results: All MRI‐derived indices were significantly higher in hemangioblastoma than in brain metastasis. ROC analysis revealed the best performance with APT‐related indices (AUC = 1.000), although pairwise comparisons showed no significant difference between the mean ADC and mean rCBV. Conclusions: APT imaging is a useful and robust imaging tool for differentiating hemangioblastoma from metastasis.