A recent update on new synthetic chiral compounds with antileishmanial activity. Issue 10 (10th August 2022)

• Record Type: Journal Article
• Authors: Verboni, Michele; Olivieri, Diego; Lucarini, Simone
• Is Part Of: Chirality. Volume 34:Issue 10(2022)
• Page Start: 1279
• Page End: 1297
• Publication Date: 2022-08-10
• Subjects: chiral catalysis -- chiral pool -- chiral resolution -- imidazoxazines -- imidazoxazoles -- kinetic resolution -- leishmania -- medicinal chemistry -- natural products -- peptides; Chirality -- Periodicals; Pharmaceutical chemistry -- Periodicals; 541.22
• DOI: 10.1002/chir.23494
• Languages: English
• ISSNs: 0899-0042

Abstract

Abstract: Parasitic diseases, including malaria, leishmaniasis, and trypanosomiasis, affect billions of people and are responsible for almost 500, 000 deaths/year. In particular, leishmaniasis, a neglected tropical disease, is considered a global public health problem because current drugs have several drawbacks including to toxicity, high cost, and drug resistance, which result in a lack of effective and readily available therapies. Therefore, the synthesis of new, safe, and effective molecules still requires the attention of the scientific community. Moreover, it is well known that chirality plays a crucial role in the antiparasitic activity of molecules, driving the design of their synthesis. Therefore, in this review we report a recent update on new chiral compounds with promising antileishmanial activity, focusing on synthetic approaches. Where reported, in most cases the enantiopure compound has shown better potency against the protozoa than its enantiomer or corresponding racemic mixture. Abstract : ∎