Visible-light photocatalytic radical addition–translocation–cyclization to construct sulfonyl-containing azacycles. Issue 73 (24th August 2022)

• Record Type: Journal Article
• Authors: Liang, Yu-Qing; Xu, Yi-Xin; Cai, Zhong-Jian; Ji, Shun-Jun
• Is Part Of: Chemical communications. Volume 58:Issue 73(2022)
• Page Start: 10206
• Page End: 10209
• Publication Date: 2022-08-24
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d2cc03799h
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A novel visible-light photocatalytic radical addition–translocation–cyclization (RATC) approach for the efficient synthesis of sulfonyl-containing azacycles is described. Abstract : Herein, a novel visible-light photocatalytic radical addition–translocation–cyclization (RATC) approach for the efficient synthesis of sulfonyl-containing azacycles is described. The reaction delivers a wide range of monocyclic, bicyclic and polycyclic azacycles by using easily prepared sodium sulfinates and N -homopropargylic amines as starting materials. Instead of the traditionally used toxic tin reagents and thermally hazardous azos in the RATC process, clean, renewable and sustainable visible light combined with a catalytic amount of photosensitizer is used in this process. Moreover, the successful transformation of some drug derivatives further highlights the potential application of this procedure.