A near-infrared squaraine dye for Cu2+-specific detection and fluorescence imaging in living cells and mice. (October 2022)

• Record Type: Journal Article
• Authors: Yu, Lijia; Fan, Xinli; Zhao, Han; Ding, Chunguang; Zhang, Yinglin; Fan, Jingguang; Tang, Xinjing
• Is Part Of: Dyes and pigments. Volume 206(2022)
• Publication Date: 2022-10
• Subjects: Squaraine dye -- Copper ion -- Near-infrared probe -- living cells -- Mice; Tris Trihydroxymethylaminomethane buffer -- PBS 1 × Phosphate Buffer Saline -- DMF Dimethyl Formamide -- DMSO Dimethylsulfoxide -- ACN Acetonitrile -- FI Fluorescence Intensity; Dyes and dyeing -- Periodicals; Pigments -- Periodicals; 667.2
• DOI: 10.1016/j.dyepig.2022.110600
• Languages: English
• ISSNs: 0143-7208

Abstract

Abstract: Herein, a highly selective and sensitive squaraine dye (F-0) for Cu 2+ detection was developed. Upon addition of Cu 2+, F-0 could greatly decrease absorption peak accompanying with fluorescent quenching about 170 folds. The detection limit can reach as low as 7.2 nmol/L. F-0 showed excellent water solubility and achieved naked eye detection of Cu 2+ . A paper strip pre-stained with F-0 solution was fabricated and showed color changed from blue to colorless upon addition of Cu 2+ . F-0 exhibited highly specific to Cu 2+ over other metal ions. Furthermore, on the basic of low cell cytotoxicity, F-0 could be utilized to monitor Cu 2+ in living cell and mice via fluorescence imaging. These results showed that F-0 has great potential for a more complex applications. Graphical abstract: Image 1