Three new 2-(2-phenylethyl)chromones from 'Chong-lou' agarwood of Aquilaria sinensis. (October 2022)

• Record Type: Journal Article
• Authors: Su, Xin; Cai, Cai-Hong; Dong, Wen-Hua; Gai, Cui-Juan; Wang, Ya-Li; Mei, Wen-Li; Xu, Xing-Lian; Dai, Hao-Fu; Chen, Hui-Qin
• Is Part Of: Phytochemistry letters. Volume 51(2022)
• Page Start: 86
• Page End: 90
• Publication Date: 2022-10
• Subjects: Chong-lou' agarwood -- Aquilaria sinensis -- 2-(2-phenylethyl)chromones -- Cytotoxicity; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2022.07.009
• Languages: English
• ISSNs: 1874-3900

Abstract

Abstract: Three new 2-(2-phenylethyl)chromones (1, 2 and 3 ), together with four known analogues 4 ~7 were isolated from 'Chong-lou' agarwood originating from Aquilaria sinensis for the first time. Their new structures were elucidated on the basis of spectroscopic techniques (UV, IR, MS, 1D and 2D NMR), as well as by comparison with the literature data. Compounds 6 and 7 exhibited significant cytotoxicity against human cancer cell line K562 with IC50 values of 19.79 ± 0.03 and 21.39 ± 0.05 μ M, respectively. Graphical Abstract: ga1 Highlights: Three new 2-(2-phenylethyl)chromones were obtained from 'Chong-lou' agarwood of Aquilaria sinensis . The new structures were deduced by spectroscopic analysis, ECD calculation and X-ray crystallographic data. Compounds 6 and 7 exhibited significant cytotoxicity against human cancer cell line K562.