Effect of Vitamin D Supplementation on Inflammatory Biomarkers in School-Aged Children with Attention Deficit Hyperactivity Disorder. (22nd August 2022)

• Record Type: Journal Article
• Authors: Samadi, Mahsa; Gholami, Fatemeh; Seyedi, Marzieh; Jalali, Mahmoud; Effatpanah, Mohammad; Yekaninejad, Mir Saeid; Abdolahi, Mina; Chamari, Maryam; Mohammadzadeh Honarvar, Niyaz
• Other Names: Saad Khaled Academic Editor.
• Is Part Of: International journal of clinical practice. Volume 2022(2022)
• Publication Date: 2022-08-22
• Subjects: Clinical medicine -- Periodicals; Medicine -- Periodicals; 610.5
• DOI: 10.1155/2022/1256408
• Languages: English
• ISSNs: 1368-5031

Abstract

Abstract : Background and Objective. Attention deficit hyperactivity disorder (ADHD) is one of the most prevalent psychiatric and developmental disorders in children. Low serum vitamin D concentration and elevated inflammation biomarkers might be involved in neuropsychiatric disorders, such as ADHD. The purpose of this study was to evaluate the effect of vitamin D supplementation on TNF- α and IL-6 levels in children with attention deficit hyperactivity disorder. Method . This randomized double-blind, placebo-controlled trial was conducted on 75 school-aged children with a diagnosis of ADHD based on DSM-V criteria. Children were randomly allocated to receive either vitamin D3 (2000 IU/day) or a placebo for 3 months. Serum IL-6, TNF- α, and 25(OH) D were assessed before and after the intervention to determine the effects of vitamin D on the highlighted parameters. Results . Serum levels of 25(OH) D increased significantly in the vitamin D group (P = 0.01 ). However, no significant differences in serum IL-6 and TNF- α were found between both groups at the baseline and at the end of the intervention. Conclusion . The findings revealed that vitamin D supplementation for 3 months is not efficacious in reducing inflammatory cytokines in children with ADHD. Further studies are required to confirm these results.