Proteinuria in neuronal intranuclear inclusion disease. Issue 2 (6th February 2018)

• Record Type: Journal Article
• Authors: Fukai, Yuta; Yorimitsu, Daisuke; Nishimura, Hirotake; Kutoku, Yumiko; Sasaki, Tamaki; Kashihara, Naoki; Ohsawa, Yutaka; Sunada, Yoshihide
• Is Part Of: Neurology and clinical neuroscience. Volume 6:Issue 2(2018:Mar.)
• Page Start: 51
• Page End: 53
• Publication Date: 2018-02-06
• Subjects: magnetic resonance imaging -- neuronal intranuclear inclusion disease -- proteinuria -- renal biopsy; Neurology -- Periodicals; Neurosciences -- Periodicals; 616.8
• DOI: 10.1111/ncn3.12182
• Languages: English
• ISSNs: 2049-4173

Abstract

Abstract: Recently, clinical features of adult‐onset neuronal intranuclear inclusion disease have gradually become characterized by premortem diagnoses based on eosinophilic, ubiquitin‐positive intranuclear inclusions demonstrated using skin biopsy specimens. A 65‐year‐old healthy woman with proteinuria was admitted because of cognitive impairment and walking instability. She had frontal lobe dysfunction and sensory ataxia with high‐signal‐intensity lesions in the corticomedullary junction on performing diffusion‐weighted brain magnetic resonance imaging. She was incidentally diagnosed with adult‐onset sporadic neuronal intranuclear inclusion disease based on the presence of intranuclear inclusions in renal biopsy specimens. Proteinuria might be a non‐neuronal symptom of neuronal intranuclear inclusion disease because no other causes for proteinuria were found on renal testing.