Combination therapy between prophylactic and therapeutic human papillomavirus (HPV) vaccines with special emphasis on implementation of nanotechnology. (October 2022)

• Record Type: Journal Article
• Authors: Gohar, Asmaa; Ali, Aya A.; Elkhatib, Walid F.; El-Sayyad, Gharieb S.; Elfadil, Dounia; Noreddin, Ayman M.
• Is Part Of: Microbial pathogenesis. Volume 171(2022)
• Publication Date: 2022-10
• Subjects: Human papillomavirus -- Cancer -- Pathogenesis -- Therapeutic vaccine -- Nanotechnology; Pathogenic microorganisms -- Periodicals; Pathology, Molecular -- Periodicals; Communicable Diseases -- microbiology -- Periodicals; Communicable Diseases -- parasitology -- Periodicals; Micro-organismes pathogènes -- Périodiques; Pathologie moléculaire -- Périodiques; Electronic journals; 616.9041
• DOI: 10.1016/j.micpath.2022.105747
• Languages: English
• ISSNs: 0882-4010

Abstract

Abstract: Human papillomavirus (HPV) is the most prevalent sexually transmitted disease in the world. Even though preventive vaccines against HPV are effective, the effective treatment of HPV infections is much less satisfactory due to multi-drug resistance and secondary adverse effects. Nanotechnology was employed for the delivery of anti-cancer drugs to increase the effectiveness of the treatment and minimize the side effects. Nanodelivery of both preventive and therapeutic HPV vaccines has also been studied to boost vaccine efficacy. Overall, such developments suggest that the nanoparticle-based vaccine might emerge as the most cost-effective way to prevent and treat HPV cancer, assisted or combined with another nanotechnology-based therapy. This review focuses on the current knowledge on pathogenesis and vaccines against HPV, highlighting the current value and perspective regarding the widespread diffusion of HPV vaccines-based nanomaterials. The ongoing advancements in the design of vaccines-based nanomaterials are expanding their therapeutic roles against HPV. Graphical abstract: Image 1 Highlights: Cervical cancer is predominantly caused by infection via human papillomavirus (HPV). Combination therapy between prophylactic and therapeutic HPV vaccines are reviewed. Therapeutic vaccines-based nanomaterials are promising for cervical cancer treatment. Strong need for new technologies for diagnosis, treatment, and prevention to fight against cervical cancer.