Physiological responses in Nile tilapia (Oreochromis niloticus) induced by combined stress of environmental salinity and triphenyltin. (September 2022)

• Record Type: Journal Article
• Authors: Xing, Shaoying; Li, Ping; He, Shuwen; Cao, Zhihan; Wang, Xu; Cao, Xuqian; Liu, Bin; Chen, Chengzhuang; You, Hong; Li, Zhi-Hua
• Is Part Of: Marine environmental research. Volume 180(2022)
• Publication Date: 2022-09
• Subjects: Salinity -- Triphenyltin -- Osmoregulation -- Energy metabolism; Marine pollution -- Environmental aspects -- Periodicals; Marine ecology -- Periodicals; Mer -- Pollution -- Aspect de l'environnement -- Périodiques; Écologie marine -- Périodiques; Electronic journals; 577.705
• DOI: 10.1016/j.marenvres.2022.105736
• Languages: English
• ISSNs: 0141-1136

Abstract

Abstract: Triphenyltin (TPT) has attracted considerable attention owing to its vitality, bioaccumulation, and lurking damage. TPT widely exists in complex salinity areas such as estuaries and coastal regions. However, there are few studies on the toxicological behavior of TPT under different salinity. In the study, juvenile Nile tilapia ( Oreochromis niloticus ) were utilized as model animals to investigate the effects of environmental relevant TPT exposure on the osmoregulation and energy metabolism in gill under different salinity. The results showed that salinity and TPT single or combined exposure affected the morphology of the gill tissue. After TPT exposure, Na + -K + -ATPase (NKA) activity significantly decreased at 0 ppt, while NKA and Ca 2+ -Mg 2+ -ATPase (CMA) activities significantly increased at 15 ppt. In addition, significantly higher succinate dehydrogenase (SDH) and lactate dehydrogenase (LDH) activities were found in the control fish compared to the TPT-exposed ones at 15 ppt. Quantitative real-time PCR results showed that TPT exposure affected the expression of osmoregulation and energy metabolism-related genes under different salinity. Overall, TPT exposure interfered with osmoregulation and energy metabolism under different salinity. The study will provide reference data for assessing the toxicity of organotin compounds in complex-salinity areas. Graphical abstract: Image 1 Highlights: Salinity and TPT exposure lead to morphological changes in tilapia gill. Salinity and TPT exposure resulted in dysregulation of osmoregulation biomarkers. Salinity and TPT exposure interfered with energy metabolism.