Clinical efficacy of oligonol® supplementation on metabolism and muscle health in middle-aged and older adults: A double-blinded randomized controlled trial. (November 2022)

• Record Type: Journal Article
• Authors: Peng, Li-Ning; Lin, Ming-Hsien; Lee, Huei-Fang; Hsu, Chia-Chia; Chang, Sue-Joan; Chen, Liang-Kung
• Is Part Of: Archives of gerontology and geriatrics. Volume 103(2022)
• Publication Date: 2022-11
• Subjects: Metabolism -- Muscle health -- Older adults -- Oligonol®; Aging -- Periodicals; Geriatrics -- Periodicals; Gerontology -- Periodicals; Electronic journals; 305.26
• DOI: 10.1016/j.archger.2022.104784
• Languages: English
• ISSNs: 0167-4943

Abstract

Highlights: The evidence between nutrition supplement and muscle health significantly increased. A low-molecular-weight polyphenol, Oligonol®, exhibits metabolic and anti-inflammatory effect. Oligonol supplementation significantly improved physical performance and muscle mass in men. Abstract: Background: Oligonol® is a low-molecular-weight polyphenol that has biological effects on metabolism in animals. However, little is known about its roles in muscle function and muscle quality in middle-aged and older adults. Methods: 120 participants were enrolled for study based on 1:1 randomization. Participants in the intervention group were provided 200 mg oligonol® prepared as capsules, and 200 mg placebo (dextrin) was provided in control group. Results: Data from 103 participants (52 in the intervention group and 51 in the control group) were available for analysis. The mean age of all participants was 64.0 ± 8.2 years, and two-thirds of the participants were females. Baseline demographic characteristics, functional assessment, laboratory data and muscle parameters were similar between groups. Hip circumference decreased ( p = 0.009) during the study period, and the 6-m walking speed increased ( p = 0.001) in women in the intervention group. In contrast, 6-m walking speed, 6-min walking distance and handgrip strength were significantly improved in men in the intervention group, but increased total body fat percentage ( p = 0.038) and decreased mid-thigh cross-muscle area (CMA) ( p = 0.007) were observed in the control group. Compared to the control group, the 12-week interval change in the percentage of mid-thigh CMA was maintained in men in the intervention group but was significantly decreased in the control group ( p = 0.03, 95% CI:0.002-0.05). Conclusions: Oligonol supplementation (200 mg per day) significantly improved physical performance and muscle mass in men. Further studies are needed to confirm the potential favorable effects of oligonol® supplementation.