Acylated secoiridoid glucosides isolated from the fruit extract of Symplocos lucida inhibit β-glucuronidase. (October 2022)

• Record Type: Journal Article
• Authors: Higashi, Reina; Ohta, Emi; Nehira, Tatsuo; Ômura, Hisashi; Uy, Mylene M.; Ohta, Shinji
• Is Part Of: Phytochemistry letters. Volume 51(2022)
• Page Start: 127
• Page End: 131
• Publication Date: 2022-10
• Subjects: Symplocos lucida (Thunb.) Siebold & Zucc. -- Symplocaceae -- Fruit -- Symplolucidins A and B -- Secoiridoid glucoside -- β-glucuronidase inhibitor; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2022.08.008
• Languages: English
• ISSNs: 1874-3900

Abstract

Abstract: Two new acylated secoiridoid glucosides, designated symplolucidins A and B, were isolated from the fruit extract of Symplocos lucida (Thunb.) Siebold & Zucc. Their structures, including their absolute configurations, were elucidated by extensive spectroscopic analyses and chemical reactions. They were found to exhibit β-glucuronidase inhibitory effect. Graphical Abstract: ga1 Highlights: Two new secoiridoid glucosides were isolated from the fruits of Symplocos lucida. The structures were characterized by spectroscopic methods. β-Glucuronidase inhibitory activity was evaluated.