Mental health disorders are more common in patients with Hodgkin lymphoma and may negatively impact overall survival. Issue 19 (2nd August 2022)

• Record Type: Journal Article
• Authors: Tao, Randa; Chen, Yuji; Kim, Seungmin; Ocier, Krista; Lloyd, Shane; Poppe, Matthew M.; Lee, Catherine J.; Glenn, Martha J.; Smith, Ken R.; Fraser, Alison; Deshmukh, Vikrant; Newman, Michael G.; Snyder, John; Rowe, Kerry G.; Gaffney, David K.; Haaland, Ben; Hashibe, Mia
• Is Part Of: Cancer. Volume 128:Issue 19(2022)
• Page Start: 3564
• Page End: 3572
• Publication Date: 2022-08-02
• Subjects: anxiety -- depression -- Hodgkin lymphoma -- mental health -- survivorship; Cancer -- Periodicals; Cancer -- Cytopathology -- Periodicals; 616.99405
• DOI: 10.1002/cncr.34359
• Languages: English
• ISSNs: 0008-543X

Abstract

Abstract : Background: Long‐term mental health outcomes were characterized in patients who were diagnosed with Hodgkin lymphoma (HL), and risk factors for the development of mental health disorders were identified. Methods: Patients who were diagnosed with HL between 1997 and 2014 were identified in the Utah Cancer Registry. Each patient was matched with up to five individuals from a general population cohort identified within the Utah Population Database, a unique source of linked records that includes patient and demographic data. Results: In total, 795 patients who had HL were matched with 3575 individuals from the general population. Compared with the general population, patients who had HL had a higher risk of any mental health diagnosis (hazard ratio, 1.77; 95% confidence interval, 1.57–2.00). Patients with HL had higher risks of anxiety, depression, substance‐related disorders, and suicide and intentional self‐inflicted injuries compared with the general population. The main risk factor associated with an increased risk of being diagnosed with mental health disorders was undergoing hematopoietic stem cell transplantation, with a hazard ratio of 2.06 (95% confidence interval, 1.53–2.76). The diagnosis of any mental health disorder among patients with HL was associated with a detrimental impact on overall survival; the 10‐year overall survival rate was 70% in patients who had a mental health diagnosis compared with 86% in those patients without a mental health diagnosis ( p < .0001). Conclusions: Patients who had HL had an increased risk of various mental health disorders compared with a matched general population. The current data illustrate the importance of attention to mental health in HL survivorship, particularly for patients who undergo therapy with hematopoietic stem cell transplantation. Abstract : Hodgkin lymphoma survivors had an increased risk of mental health disorders, and undergoing stem cell transplantation was the only treatment‐related risk factor. Survivors who had a mental health disorder had worse overall survival compared with those who did not develop a mental health disorder.