African American race as a risk factor associated with a second primary lung cancer after initial primary head and neck cancer. Issue 10 (17th June 2022)

• Record Type: Journal Article
• Authors: Shao, Yusra F.; Kim, Seongho; Cramer, John D.; Farhat, Dina; Hotaling, Jeffrey; Raza, Syed Naweed; Yoo, George; Lin, Ho‐sheng; Kim, Harold; Sukari, Ammar; Nagasaka, Misako
• Is Part Of: Head & neck. Volume 44:Issue 10(2022)
• Page Start: 2069
• Page End: 2076
• Publication Date: 2022-06-17
• Subjects: African American -- head and neck cancer -- head and neck neoplasms -- lung cancer -- lung neoplasms; Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.27107
• Languages: English
• ISSNs: 1043-3074

Abstract

Abstract: Background: Initial primary head and neck cancer (IPHNC) is associated with second primary lung cancer (SPLC). We studied this association in a population with a high proportion of African American (AA) patients. Methods: Patients with IPHNC and SPLC treated between 2000 and 2017 were reviewed for demographic, disease, and treatment‐related characteristics and compared to age‐and‐stage‐matched controls without SPLC. Logistic and Cox regression models were used to analyze the relationship of these characteristics with the development of SPLC and overall survival (OS). Results: Eighty‐seven patients and controls were compared respectively. AA race was associated with a significantly higher risk of developing SPLC (OR 2.92, 95% CI 1.35–6.66). After correcting for immortal time bias, patients with SPLC had a significantly lower OS when compared with controls (HR 0.248, 95% CI 0.170–0.362). Conclusions: We show that AA race is associated with an increased risk of SPLC after IPHNC; reasons of this increased risk warrant further investigation.