Effluent N‐terminal expressed in renal cell carcinoma/mesothelin predicts increased peritoneal permeability in patients undergoing peritoneal dialysis. Issue 5 (17th January 2022)

• Record Type: Journal Article
• Authors: Idei, Mayumi; Abe, Masaaki; Tanaka, Mototsugu; Nakata, Junichiro; Isshiki, Miwa; Hino, Okio; Miida, Takashi
• Is Part Of: Therapeutic apheresis and dialysis. Volume 26:Issue 5(2022)
• Page Start: 1014
• Page End: 1022
• Publication Date: 2022-01-17
• Subjects: biomarker -- encapsulating peritoneal sclerosis -- end‐stage kidney disease -- peritoneal damage -- peritoneal equilibration test; Hemapheresis -- Periodicals; Dialysis -- Periodicals; Blood Component Removal -- Periodicals; Renal Dialysis -- Periodicals; Hémaphérèse -- Périodiques; Dialyse -- Périodiques; Sang -- Collecte et conservation -- Périodiques; 616
• DOI: 10.1111/1744-9987.13786
• Languages: English
• ISSNs: 1744-9979

Abstract

Abstract: Introduction: We investigated whether N‐terminal and C‐terminal products of expressed in renal cell carcinoma/mesothelin (N‐ERC and C‐ERC) in peritoneal effluent can predict peritoneal permeability in patients undergoing peritoneal dialysis (PD). Methods: Thirty‐seven peritoneal effluent samples were obtained from 26 PD patients. High transport status was determined by the peritoneal equilibration test as a dialysate/plasma ratio of creatinine (D/P Cr) ≥ 0.81. Effluent cancer antigen 125 (CA125) was used as a reference. Results: Effluent N‐ERC concentration was better correlated with D/P Cr than effluent C‐ERC or CA125 concentration. In multivariate analyses, effluent N‐ERC and C‐ERC, but not CA125, were significant predictors of high transport status after adjusting for age, PD duration, and residual renal Kt/V. ROC analysis showed that effluent N‐ERC was the best predictor of high transport status among those three biomarkers. Conclusion: Effluent N‐ERC predicts increased peritoneal permeability in patients undergoing PD.