Lewis b antigen is a common ligand for genogroup I norovirus strains. Issue 9 (4th July 2022)

• Record Type: Journal Article
• Authors: Someya, Yuichi
• Other Names: Wlodawer Alexander guestEditor.
• Is Part Of: FEBS open bio. Volume 12:Issue 9(2022)
• Page Start: 1688
• Page End: 1695
• Publication Date: 2022-07-04
• Subjects: histo‐blood group antigens -- Lewis antigens -- norovirus -- virus‐like particle; Molecular biology -- Periodicals; Cytology -- Periodicals; Life sciences -- Periodicals; Biological Science Disciplines -- Periodicals; Molecular Biology -- Periodicals; Cell Biology -- Periodicals; Cytology; Life sciences; Molecular biology; Periodicals; 572.805
• DOI: 10.1002/2211-5463.13455
• Languages: English
• ISSNs: 2211-5463

Abstract

Abstract : Noroviruses are major causative agents of nonbacterial acute gastroenteritis in humans. Ten genogroups of noroviruses have been identified to date, among which genogroup I (GI) and genogroup II (GII) noroviruses are major pathogens for humans. GI and GII noroviruses are further classified into nine and 27 genotypes, respectively. Noroviruses are well known to bind to histo‐blood group antigens (HBGAs). Many studies have revealed that virus‐like particles (VLPs) from different genotypes exhibit distinct patterns of HBGA binding, but the assay conditions used in these studies were not identical. To enable comparison of the binding to HBGA of nine GI genotypes, I purified VLPs from insect cells and analysed their HBGA‐binding profiles. Although each genotype exhibited a distinct pattern of HBGA binding, Lewis b antigen was commonly recognized by all of the genogroup I strains, suggesting that this antigen plays a critical role in the pathogenesis of noroviruses. Abstract : Histo‐blood group antigens (HBGAs) are thought to be cellular attachment factors for human noroviruses. Using virus‐like particles from the genogroup I noroviruses, their HBGA‐binding profiles were investigated. Herein, I discovered that Lewis b antigen is a common ligand for all of the genogroup I strains, suggesting its critical role in the infection event.