Covid‐19 vaccination in autoimmune rheumatic diseases: A multi‐center survey from southern India. (30th June 2022)

• Record Type: Journal Article
• Authors: Mohanasundaram, Kavitha; Santhanam, Sham; Natarajan, Raja; Murugesan, Hema; Nambi, Thilagavathy; Chilikuri, Balaji; Nallasivan, Subramanian
• Is Part Of: International journal of rheumatic diseases. Volume 25:Number 9(2022)
• Page Start: 1046
• Page End: 1052
• Publication Date: 2022-06-30
• Subjects: ChAdOx1 nCoV 19 -- COVID 19 vaccines -- COVID‐19 breakthrough infections -- side effects -- vaccine hesitancy; Rheumatology -- Periodicals; Rheumatology -- Asia -- Periodicals; Rheumatology -- Pacific Area -- Periodicals; Rheumatic Diseases -- Periodicals; Connective Tissue Diseases -- Periodicals; Immune System Diseases -- Periodicals; 616.723
• DOI: 10.1111/1756-185X.14378
• Languages: English
• ISSNs: 1756-1841

Abstract

Abstract: Aim: This survey was conducted to evaluate COVID‐19 vaccination status in patients with autoimmune rheumatic diseases (AIRDs). Our objectives were to study vaccine hesitancy, adverse effects, breakthrough infections and flare of underlying disease in this population subgroup. Methods: This was a multi‐center, cross‐sectional, interview‐based survey done at 6 tertiary care centers across Tamil Nadu, in the southern part of India from September 15, 2021 to October 14, 2021. The survey questionnaire was filled up by AIRD patients attending their clinics. The survey questionnaire comprised a set of 14 questions, distributed between patient characteristics, vaccines taken, their characteristics and COVID‐19 infection. Results: There were 2092 participants, with a mean age of 47.5 ± 13.17 years. Among them, 1293 (61.81%) were vaccinated, of which 837 (64.73%) were fully vaccinated. Two‐thirds of our subjects were vaccinated with ChAdOx1 nCov‐19 (COVISHIELD) (77.64%) and 21.57% with BBV 152 (COVAXIN). Age, gender, education and comorbidities had no association with vaccine hesitancy. The commonest (421; 52.69%) reason for vaccine hesitancy was fear of side effects. The incidence (n = 72) of breakthrough infections was similar in both the vaccine groups, of which 58 (80.55%) were partially vaccinated and 14 (19.44%) were fully vaccinated. Thirty‐two patients had a flare of pre‐existing rheumatic disease. Conclusion: ChAdOx1 nCov‐19 and BBV 152 were found to be safe in patients with rheumatic diseases. Fear of side effects was the major cause of vaccine hesitancy. All adverse effects were minor and self‐limiting. Breakthrough infections and disease flares occurred only in a small subset of our cohort.