Changes in white matter functional networks during wakefulness and sleep. Issue 14 (26th May 2022)

• Record Type: Journal Article
• Authors: Yang, Yang; Wang, Shilei; Liu, Jiayi; Zou, Guangyuan; Jiang, Jun; Jiang, Binghu; Cao, Wentian; Zou, Qihong
• Is Part Of: Human brain mapping. Volume 43:Issue 14(2022)
• Page Start: 4383
• Page End: 4396
• Publication Date: 2022-05-26
• Subjects: EEG -- fluctuation amplitude -- fMRI -- functional connectivity -- NREM sleep -- white matter functional networks; Brain mapping -- Periodicals; 611.81
• DOI: 10.1002/hbm.25961
• Languages: English
• ISSNs: 1065-9471

Abstract

Abstract: Blood oxygenation level‐dependent (BOLD) signals in the white matter (WM) have been demonstrated to encode neural activities by showing structure‐specific temporal correlations during resting‐state and task‐specific imaging of fiber pathways with various degrees of correlations in strength and time delay. Previous neuroimaging studies have shown state‐dependent functional connectivity and regional amplitude of signal fluctuations in brain gray matter across wakefulness and nonrapid eye movement (NREM) sleep cycles. However, the functional characteristics of WM during sleep remain unknown. Using simultaneous electroencephalography and functional magnetic resonance imaging data during wakefulness and NREM sleep collected from 66 healthy participants, we constructed 10 stable WM functional networks using clustering analysis. Functional connectivity between these WM functional networks and regional amplitude of WM signal fluctuations across multiple low‐frequency bands were evaluated. In general, decreased WM functional connectivity between superficial and middle layer WM functional networks was observed from wakefulness to sleep. In addition, functional connectivity between the deep and cerebellar networks was higher during light sleep and lower during both wakefulness and deep sleep. The regional fluctuation amplitude was always higher during light sleep and lower during deep sleep. Importantly, slow‐wave activity during deep sleep negatively correlated with functional connectivity between WM functional networks but positively correlated with fluctuation strength in the WM. These observations provide direct physiological evidence that neural activities in the WM are modulated by the sleep–wake cycle. This study provided the initial mapping of functional changes in WM during sleep. Abstract : Using simultaneous EEG‐fMRI data during wakefulness and NREM sleep collected from 66 healthy participants, we constructed 10 stable white matter functional networks using clustering analysis. These observations provide direct physiological evidence that neural activities in the white matter are modulated by the sleep–wake cycle.