A Japanese case of successful surgical resection of cerebral cavernous malformations with a CCM2 mutation. Issue 5 (29th June 2022)

• Record Type: Journal Article
• Authors: Nomura, Emi; Omote, Yoshio; Takemoto, Mami; Hishikawa, Nozomi; Nakano, Yumiko; Yunoki, Taijun; Morihara, Ryuta; Sasaki, Tatsuya; Akagawa, Hiroyuki; Abe, Koji; Yamashita, Toru
• Is Part Of: Neurology and clinical neuroscience. Volume 10:Issue 5(2022)
• Page Start: 255
• Page End: 258
• Publication Date: 2022-06-29
• Subjects: CCM2 -- cerebral cavernous malformation -- drug‐resistant epilepsy; Neurology -- Periodicals; Neurosciences -- Periodicals; 616.8
• DOI: 10.1111/ncn3.12649
• Languages: English
• ISSNs: 2049-4173

Abstract

Abstract: Cerebral cavernous malformations (CCMs) are congenital abnormalities of cerebral vessels. Surgical resection is rarely considered for the control of epilepsy in a first seizure patient with vascular malformation. In contrast, lesions that produce repetitive or progressive symptoms should be considered for surgical resection as treatment. Herein, we report a Japanese patient with a CCM2 mutation, c.609G>A (p.K203K) substitution, who showed drug‐resistant epilepsy and dramatic improvement after surgical resection.