Cycloacceleration of Reactive Oxygen Species Generation Based on Exceedingly Small Magnetic Iron Oxide Nanoparticles for Tumor Ferroptosis Therapy. Issue 35 (3rd August 2022)

• Record Type: Journal Article
• Authors: Zhou, Huimin; Lu, Xuanyi; Du, Chao; Zhou, Zijian; Feng, Jie; Liang, Zhiyu; Xu, Yikai; Qiu, Xiaozhong; Shen, Zheyu
• Is Part Of: Small. Volume 18:Issue 35(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-08-03
• Subjects: cycloacceleration -- Fenton reaction -- ferroptosis therapy (FT) -- magnetic resonance imaging (MRI) contrast agents -- reactive oxygen species (ROS) generation; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.202202705
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract: Because of the insufficiency of hydrogen peroxide, the relatively low rate of Fenton reaction, and the active glutathione (GSH) peroxidase 4 (GPX4) in tumor cells, it is difficult to achieve a desirable efficacy of ferroptosis therapy (FT) for tumors based on nanomaterials. Inspired by the concept of "cyclotron" in physics, in this study, a new concept of cycloacceleration of reactive oxygen species (ROS) generation in tumor cells to realize high‐performance FT of tumors is proposed. Typically, a magnetic resonance imaging (MRI) contrast agent of dotted core–shell Fe3 O4 /Gd2 O3 hybrid nanoparticles (FGNPs) is prepared based on exceedingly small magnetic iron oxide nanoparticles (ES‐MIONs). Sorafenib (SFN) is loaded and poly(ethylene glycol) methyl ether‐poly(propylene sulfide)‐NH2 (mPEG‐PPS‐NH2 ) is grafted on the surface of FGNP to generate SA‐SFN‐FGNP via self‐assembly. The results of in vitro and in vivo demonstrate SA‐SFN‐FGNP can work with the acidic tumor microenvironment and endosomal conditions, Fenton reaction and system XC −, and generate cyclic reactions in tumor cells, resulting in specific cycloacceleration of ROS generation for high‐performance FT of tumors. The very high longitudinal relaxivity ( r 1, 33.43 mM −1 s −1, 3.0 T) makes sure that the SA‐SFN‐FGNP can be used for MRI‐guided FT of tumors. Abstract : To realize high‐performance ferroptosis therapy of tumors, a new concept of cycloacceleration of reactive oxygen species generation in tumor cells is proposed in this study, and an intelligent SA‐SFN‐FGNP nanoparticle is developed to prove the feasibility of this concept.