Stepwise pluripotency transitions in mouse stem cells. (29th July 2022)

• Record Type: Journal Article
• Authors: Endoh, Mitsuhiro; Niwa, Hitoshi
• Is Part Of: EMBO reports. Volume 23:Number 9(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-07-29
• Subjects: epiblast -- formative -- naïve -- pluripotency -- primed; Molecular biology -- Periodicals; Molecular Biology -- Periodicals; Molecular biology; Periodicals; 572.8
• DOI: 10.15252/embr.202255010
• Languages: English
• ISSNs: 1469-221X

Abstract

Abstract: Pluripotent cells in mouse embryos, which first emerge in the inner cell mass of the blastocyst, undergo gradual transition marked by changes in gene expression, developmental potential, polarity, and morphology as they develop from the pre‐implantation until post‐implantation gastrula stage. Recent studies of cultured mouse pluripotent stem cells (PSCs) have clarified the presence of intermediate pluripotent stages between the naïve pluripotent state represented by embryonic stem cells (ESCs—equivalent to the pre‐implantation epiblast) and the primed pluripotent state represented by epiblast stem cells (EpiSCs—equivalent to the late post‐implantation gastrula epiblast). In this review, we discuss these recent findings in light of our knowledge on peri‐implantation mouse development and consider the implications of these new PSCs to understand their temporal sequence and the feasibility of using them as model system for pluripotency. Abstract : Cultured mouse pluripotent stem cells are characterised by intermediate states between naïve and primed pluripotency. This review characterises these intermediates in the light of mouse peri‐implantation development and discusses their use as model systems.