Genetic polymorphisms in DNA repair genes and their association with risk of cervical cancer: A systematic review and meta‐analysis. Issue 9 (22nd June 2022)

• Record Type: Journal Article
• Authors: Shao, Xueting; Yang, Xiaole; Liu, Ying; Song, Qingxia; Pan, Xin; Chen, Wansu; Jiang, Wei; Xu, Dan; Song, Yuanyuan; Chen, Renshou
• Is Part Of: Journal of obstetrics and gynaecology research. Volume 48:Issue 9(2022)
• Page Start: 2405
• Page End: 2418
• Publication Date: 2022-06-22
• Subjects: cervical cancer -- DNA repair genes -- genetic polymorphism -- risk; Gynecology -- Periodicals; Obstetrics -- Periodicals; 618.1005
• DOI: 10.1111/jog.15325
• Languages: English
• ISSNs: 1341-8076

Abstract

Abstract: Background: There have been a large number of epidemiologic studies regarding the association between genetic polymorphisms in DNA repair genes and onset of cervical cancer. However, results are inconsistent. Methods: Articles published before June 2021 and regarding genetic polymorphisms in DNA repair genes and cervical cancer were searched in following databases: PubMed, Web of Science, Google Scholar, and CNKI. With at least three articles for each polymorphism, we made meta‐analysis to compute multivariate odds ratios (ORs) and their 95% confidence intervals (CIs). Results: The present study showed significant associations between XRCC1 Arg399Gln polymorphisms and risk of cervical cancer in Asian, whereas no significant association between them were showed in Caucasian (Asian: GA vs. GG: OR = 1.27, 95%CI 1.06–1.52; AA vs. GG: OR = 1.91, 95%CI 1.29–2.83; GA + AA vs. GG: OR = 1.36, 95%CI 1.12–1.65; AA vs. GG + GA: OR = 1.66, 95%CI 1.17–2.37; Caucasian: GA vs. GG: OR = 1.08, 95%CI 0.83–1.41; AA vs. GG: OR = 2.18, 95%CI 0.75–6.31; GA + AA vs. GG: OR = 1.23, 95%CI 0.85–1.78; AA vs. GG + GA: OR = 1.70, 95%CI 0.69–4.18). In addition, there were significant associations between ERCC2 rs13181 polymorphisms and risk of cervical cancer in Asian (AC vs AA: OR = 0.53, 95%CI 0.37–0.75, I 2 = 0.0%, p value of Q test = 0.847; AC + CC vs AA: OR = 0.50, 95%CI 0.36–0.70, I 2 = 0.0%, p value of Q test = 0.856). Conclusions: The meta‐analysis showed that there were significant associations between XRCC1 Arg399Gln and ERCC2 rs13181 polymorphisms and risk of cervical cancer.