Transition‐Metal‐Free N‐Functionalization of Benzimidazoles and Related Azaheterocycles with α‐Acyloxy Sulfides. Issue 17 (3rd August 2022)

• Record Type: Journal Article
• Authors: Fang, Yingchao; Wang, Manman; Hao, Wei; Meng, Yinggao; Yu, Wenquan; Chang, Junbiao
• Is Part Of: Advanced synthesis & catalysis. Volume 364:Issue 17(2022)
• Page Start: 2922
• Page End: 2925
• Publication Date: 2022-08-03
• Subjects: N-functionalization -- transition-metal-free -- benzimidazole -- azaheterocycle -- α-acyloxy sulfide; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.202200502
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: Direct N ‐functionalization of benzimidazoles and related azaheterocycles has been achieved using readily accessible α ‐acyloxy sulfides under transition metal‐free conditions. In the presence of the base, potassium carbonate, a variety of N ‐functionalized azaheterocyclic compounds bearing an N ‐alkyl ester moiety were synthesized from corresponding heterocyclic precursors. The present reaction does not use transition metals, is operationally simple, and has broad substrate scope. Abstract :