Silica‐based Nanoparticles for Enzyme Immobilization and Delivery. Issue 17 (26th July 2022)

• Record Type: Journal Article
• Authors: Zhao, Liang; Zhang, Yue; Yang, Yannan; Yu, Chengzhong
• Is Part Of: Chemistry, an Asian journal. Volume 17:Issue 17(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-07-26
• Subjects: Silica nanoparticles -- enzyme delivery -- immobilization -- cancer therapy -- antibiosis -- nanomotor; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/asia.202200573
• Languages: English
• ISSNs: 1861-4728

Abstract

Abstract: Enzymes play an indispensable role in biosystems, catalyzing a variety of chemical and biochemical reactions with exceptionally high efficiency and selectivity. These features render them uniquely positioned in developing novel catalytic systems and therapeutics. However, their practical application is largely hindered by the vulnerability, low reusability and the inability to overcome the biological barriers of enzymes. Silica‐based nanoparticles (SNPs) are a classic family of nanomaterials with tunable physicochemical properties, making them ideal candidates to address the intrinsic shortcomings of natural enzymes. SNPs not only improve the activity and durability of enzymes, but also provide precise spatiotemporal control over their intracellular as well as systemic biodistributions for boosting the catalytic outcome. Herein, the recent progress in SNPs for enzyme immobilization and delivery is summarized. The therapeutic applications, including cancer therapy and bacterial inhibition, are particularly highlighted. Our perspectives in this field, including current challenges and possible future research directions are also provided. Abstract : Silica‐based nanoparticles (SNPs) provide an ideal platform to address the intrinsic shortcomings of enzymes, including vulnerability, low reusability and inability to overcome biological barriers. In this concept, we summarize the recent progress in SNPs for enzyme immobilization and delivery, with a particular highlight on the therapeutic applications. Our perspectives on the current challenges and possible future directions are also provided.