Association of alcohol drinking with incident type 2 diabetes and pre‐diabetes: The Guangzhou Biobank Cohort Study. Issue 6 (28th May 2022)

• Record Type: Journal Article
• Authors: Li, Mei Jiao; Ren, Jing; Zhang, Wei Sen; Jiang, Chao Qiang; Jin, Ya Li; Lam, Tai Hing; Cheng, Kar Keung; Thomas, G. Neil; Xu, Lin
• Is Part Of: Diabetes/metabolism research and reviews. Volume 38:Issue 6(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-05-28
• Subjects: alcohol dehydrogenase‐1B -- alcohol drinking -- aldehyde dehydrogenase‐2 -- fasting glucose -- impaired fasting glucose -- type 2 diabetes; Diabetes -- Periodicals; Metabolism -- Periodicals; 616.642
• DOI: 10.1002/dmrr.3548
• Languages: English
• ISSNs: 1520-7552

Abstract

Abstract: Aims: We examined associations of baseline alcohol drinking with incident type 2 diabetes (T2D) or impaired fasting glucose (IFG), and explore whether the associations were modified by genetic polymorphisms of aldehyde dehydrogenase‐2 ( ALDH2 ) and alcohol dehydrogenase‐1B ( ADH1B ). Materials and methods: All participants were aged 50+ (mean = 60.45; standard deviation = 6.88) years. Information of alcohol consumption was collected at baseline from 2003 to 2008. Incident T2D was defined as fasting glucose ≥7.0 mmol/L or post‐load glucose ≥11.1 mmol/L at follow‐up examination (2008–2012), self‐reported T2D and/or initiation of hypoglycaemia medication or insulin during follow‐up. Impaired fasting glucose was defined as fasting glucose ≥5.6 mmol/L and <7 mmol/L. Results: Of 15, 716 participants without diabetes and 11, 232 participants without diabetes and IFG at baseline, 1624 (10.33%) developed incident T2D and 1004 (8.94%) developed incident IFG during an average 4 years of follow‐up. After multivariable adjustments, compared with never drinking, occasional or moderate alcohol drinking was not associated with risk of incident hyperglycaemia (T2D + IFG) (odds ratio (OR) = 1.10, 95% confidence interval (CI) 0.95–1.27, and 0.90 (0.69–1.18), respectively), whereas heavy alcohol drinking was associated with a higher risk of incident hyperglycaemia (T2D + IFG) (OR = 1.82, 95% CI 1.24–2.68). No interactions of sex, overweight/obesity and genetic polymorphisms of ADH1B / ALDH2 genes with alcohol drinking on incident T2D and/or IFG were found ( P for interaction from 0.12 to 0.85). Conclusions: Our results support a detrimental effect of heavy alcohol use on IFG and T2D. No protective effect was found for those carrying lower risk alleles for ADH1B / ALDH2 genes.