Conditionally designed luminescent DNA crystals doped by Ln3+(Eu3+/Tb3+) complexes or fluorescent proteins with smart drug sensing property. Issue 34 (15th June 2022)

• Record Type: Journal Article
• Authors: Xiu, Dan; Zhao, Sibo; Li, Zhenhua; Xu, Yanan; Wang, Yao; Zhu, Zhijun; Zhang, Min; Snow, Christopher D.; Belfiore, Laurence A.; Tang, Jianguo
• Is Part Of: Journal of materials chemistry. Volume 10:Issue 34(2022)
• Page Start: 6443
• Page End: 6452
• Publication Date: 2022-06-15
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/d2tb00847e
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : Porous DNA crystals with high intrinsic biocompatibility were designed to be used as scaffold materials, loaded with fluorescent guest molecules (fluorescent proteins/rare earth complexes) to detect anti-cancer drugs. Abstract : In this work, a designed porous DNA crystal with high intrinsic biocompatibility was used as the scaffold material to load fluorescent guest molecules to detect anti-cancer drugs. It is shown here that the synthesized crystals have the characteristics consistent with the designed large solvent channels, and can therefore accommodate guest molecules such as fluorescent proteins that cannot be accommodated by less porous crystals. Eu(TTA)3 phen and Tb(acac)3 phen lanthanide complexes were individually noncovalently loaded into the porous crystals, resulting in hybrid luminescent DNA crystals. Emodin, an anti-cancer, anti-tumor, anti-inflammatory drug, was found to quench lanthanide complexes in solution or in crystals. Notably, emodin is the active ingredient of Lianhua Qingwen Capsule, an anti-COVID-19 drug candidate. Therefore, the porous DNA crystals reported here have potential applications as a biocompatible and theranostic delivery biomaterial for functional macromolecules.