Bayesian network analysis of long-term oncologic outcomes of open, laparoscopic, and robot-assisted radical cystectomy for bladder cancer. Issue 34 (26th August 2022)

• Record Type: Journal Article
• Authors: Dong, Lin; Xiaoli, Feng; Ya, Lu; Dan, Wu; Jingwen, Hu; Xun, Liu; Shujin, Chen; Zhijun, Zhou; Tian, Zhang; Hao, Luo; Chuanlang, Yi; Guangrong, Chen; Xiaodong, Wang; Gewen, Luo; Yichi, Zhang; Pei, Cao; Yang, Liu; Youliang, Wang
• Is Part Of: Medicine. Volume 101:Issue 34(2022)
• Page Start: e30291
• Publication Date: 2022-08-26
• Subjects: Bayesian network analysis -- bladder cancer -- laparoscopic radical cystectomy -- long-term oncologic outcomes -- open radical cystectomy -- robot-assisted radical cystectomy; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000030291
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract : Background: To understand the long-term oncologic outcomes of open radical cystectomy (ORC) versus laparoscopic radical cystectomy (LRC) versus robot-assisted radical cystectomy (RARC) for bladder cancer (BCa). Therefore, we performed the conventional meta-analysis and network meta-analysis to evaluate the long-term oncologic outcomes of ORC, LRC, and RARC for BCa. Methods: A systematic search of PubMed, Embase, Cochrane Library, Medline, and Web of science was performed up until July 1, 2021. Long-term oncologic outcomes include the 5-year overall survival (OS) rate, the 5-year recurrence-free survival (RFS) rate, and the 5-year cancer specific-survival (CSS) rate. The Bayesian network analysis has been registered in PROSPERO (CRD42020208396). Results: We found that 10 articles (including 3228 patients) were included in our Bayesian network analysis. No significant differences were found between ORC, LRC, and RARC in long-term oncologic outcomes in either direct meta-analysis or network meta-analysis. Therefore, the clinical effects of 5-year OS, RFS, and CSS of RARC, LRC, and ORC are similar. But LRC may be ranked first in 5-year OS, RFS, and CSS compared to other surgical approaches by probabilistic analysis ranking via Bayesian network analysis. Conclusion: We found that there were no statistical differences in the 3 surgical approaches of RAPC, LPC, and OPC for Bca in long-term oncologic outcomes by direct meta-analysis. However, Subtle differences between these surgical approaches can be concluded that LRC may be a better surgical approach than RARC or ORC in long-term oncologic outcomes by probabilistic analysis ranking via Bayesian network analysis. Moreover, we need a large sample size and more high-quality studies to improve and verify further.