Teaching NeuroImage: Cerebral Amyloid Angiopathy–Related Inflammation: An Interesting Evolution of Imaging Findings. (2nd August 2022)

• Record Type: Journal Article
• Authors: Dudley, Alex; Sweeney, Kieron; Looby, Seamus; Farrell, Michael; McGovern, Eavan
• Is Part Of: Neurology. Volume 99:Number 5(2022)
• Page Start: 216
• Page End: 217
• Publication Date: 2022-08-02
• Subjects: Neurology -- Periodicals; Neurology -- Periodicals; Neurologie -- Périodiques; 616.8
• DOI: 10.1212/WNL.0000000000200833
• Languages: English
• ISSNs: 0028-3878

Abstract

Abstract : A 77-year-old previously well woman presented with confusion, visual hallucinations, and signs of parietal lobe dysfunction, preceded by 5 days of headache. MRI of the brain demonstrated diffuse sulcal fluid-attenuated inversion recovery hyperintensities (Figure, A) and subtle leptomeningeal enhancement. Susceptibility-weighted imaging (SWI) was normal (Figure, B). Neurosurgical biopsy-confirmed cerebral amyloid angiopathy with perivascular inflammation (Figure, D–F). Pulsed methylprednisolone was given with excellent clinical response. MRI 7 weeks post symptom onset demonstrated widespread microhaemorrhages (Figure, C).