The association between vitamin D levels and heart rate variability in patients with type 2 diabetes mellitus. Issue 34 (26th August 2022)

• Record Type: Journal Article
• Authors: Chen, Li Ye; Ye, Xin Hua; Cheng, Jin Luo; Xue, Yun; Li, De; Shao, Jie
• Is Part Of: Medicine. Volume 101:Issue 34(2022)
• Page Start: e30216
• Publication Date: 2022-08-26
• Subjects: cardiac autonomic neuropathy -- cardiovascular disease -- diabetic complication -- heart rate variability -- type 2 diabetes mellitus -- vitamin D; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000030263
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract : To assess the association between serum vitamin D levels and heart rate variability in patients with type 2 diabetes mellitus (T2DM). This study included 469 patients who were retrospective assessed for eligibility from Changzhou Second People's Hospital, Affiliated Nanjing Medical University, between March 2013 and June 2020. A total of 191 T2DM patients were recruited and divided into 3 groups. A total of 191 patients were recruited. A significant difference was noted among groups for HbA1c ( P < .001), serum uric acid ( P = .048), and urea nitrogen ( P = .043). The Vitamin D level in deficiency, insufficiency, and sufficient was 23.17, 38.89, and 63.01 nmol/L, respectively. The insufficient group had lower levels of percentage of normal-to-normal intervals differing by more than 50 milliseconds, and the square root of the mean of the squares of the differences between adjacent normal-to-normal R peak-to-R-peak time intervals than the sufficient vitamin D group. Furthermore, patients in deficiency and insufficiency group were associated with high level of low frequency power/high frequency power as compared with sufficient vitamin D group. Finally, serum 25-hydroxyvitamin D (25(OH)D) levels were positively correlated with rMSSD ( P = .002). This study found that low serum 25(OH)D levels were associated with reduced heart rate variability parameters in patients with T2DM.