Radioiodine Uptake in Incidentally Detected Neuroendocrine Tumor: Correlative Imaging With FDG PET/CT and 68Ga-DOTATATE PET/CT. (29th October 2022)

• Record Type: Journal Article
• Authors: Hod, Nir; Lantsberg, Sophie; Levin, Daniel
• Is Part Of: Clinical nuclear medicine. Volume 47:Number 10(2022)
• Page Start: e643
• Page End: e646
• Publication Date: 2022-10-29
• Subjects: differentiated thyroid carcinoma -- neuroendocrine tumor -- radioiodine 131I whole-body scintigraphy -- false-positive uptake -- FDG PET/CT -- 68Ga-DOTATATE PET/CT; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000004254
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract: Radioiodine whole-body scintigraphy has long been used for detection of differentiated thyroid carcinoma with high avidity in functioning thyroid tissues. However, uptake is not completely specific, and "false-positive" uptake in nonthyroidal tumors have rarely been reported. Herein, we present a case of incidentally detected neuroendocrine tumor showing high radioiodine uptake initially suspected to be thyroid metastasis. Correlative imaging with FDG PET/CT and 68 Ga-DOTATATE PET/CT is presented, and literature survey is discussed. We conclude that neuroendocrine tumor should be added to the reported list of neoplasms that can show "false-positive" uptake representing a potential interpretative pitfall.