Pathoplastic effects of metabolic disorders in severe mental illness. (1st June 2022)

• Record Type: Journal Article
• Authors: Fiorani, M.; Orsolini, L.; Volpe, U.; Salvi, V.
• Is Part Of: European psychiatry. Volume 65:Supplement 1(2022)
• Page Start: S290
• Page End: S290
• Publication Date: 2022-06-01
• Subjects: severe mental illness -- metabolic syndrome -- Insuline resistance -- Pathoplastic effect; Psychiatry -- Periodicals; Mental illness -- Periodicals; Electronic journals; 616.89
• DOI: 10.1192/j.eurpsy.2022.741
• Languages: English
• ISSNs: 0924-9338

Abstract

Abstract : Introduction: Patients with severe mental illness (SMI) have a higher risk of weight gain, dyslipidemia and insulin-resistance. It was observed that insulin resistance has a pathoplastic effect: in Schizophrenia it was associated with a greater severity of negative symptoms, whereas in Bipolar Disorder it was associated with more chronicity and rapid cycling. Moreover a correlation was observed between obesity and a worse outcome in Bipolar Disorder type I. Objectives: We aimed at assessing the influence of dysmetabolisms on clinical characteristics in patients with SMI. Methods: We recruited 78 patients with SMI consecutively hospitalized in the Psychiatry Clinic of the Ospedali Riuniti of Ancona, Italy. We administered a checklist for socio-demographic and clinical features (diagnosis, age of onset, illness duration, number of episodes, number of episodes per year, suicidal attempts and comorbidities), and evaluated the following metabolic parameters: weight, height, BMI, abdominal circumference, blood pressure, total cholesterol, HDL, triglycerides, glycemia and insulinemia. We determined insulin-resistance according to the HOMA-IR model. We performed bivariate Pearson correlations to compare metabolic and socio-demographic/clinical parameters. Results: The analyses showed positive correlations between BMI and disease duration (P = 0.003), and BMI and the number of episodes (P = 0.022). Furthermore, a positive correlation was found between HOMA-IR and the number of episodes per year (P = 0.008). The associations remained statistically significant after controlling for age through partial correlations. Conclusions: Weight gain and insulin-resistance in severe mental illness are associated with a more severe SMI, as suggested by the greater number of acute episodes. Disclosure: No significant relationships.