Iron Polymaltose Infusion Effects on Bone Scintigraphy and Remodeling. (27th October 2022)

• Record Type: Journal Article
• Authors: Kang, Christine; Jiang, James Y.; Wong, Veronica; Man, Jennifer; Mansberg, Robert
• Is Part Of: Clinical nuclear medicine. Volume 47:Number 10(2022)
• Page Start: e627
• Page End: e629
• Publication Date: 2022-10-27
• Subjects: bone scan -- scintigraphy -- iron -- polymaltose; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000004171
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract: A 73-year-old woman with metastatic breast cancer and known widespread skeletal metastases was referred for bone scintigraphy. Delayed images acquired at 2 and 5 hours postinjection of 30 mCi (1089 MBq) 99m Tc-HDP demonstrated markedly reduced bony uptake, markedly increased renal activity, and significantly increased soft tissue accumulation. By contrast, appropriate skeletal uptake of 99m Tc-HDP was seen in prior bone scans. The patient had been treated for iron deficiency anemia with an infusion of 1 g of iron polymaltose approximately 22 hours before injection of 99m Tc-HDP. This phenomenon may be due to transient reduced bone resorption with increased FGF23 release secondary to IV iron supplementation.