Psychopathological and temperamental features of Late Onset versus Early Onset Bipolar Disorder. (1st June 2022)

• Record Type: Journal Article
• Authors: Orsolini, L.; Ferretti, L.; Fiorani, M.; Rocchetti, D.; Salvi, V.; Volpe, U.
• Is Part Of: European psychiatry. Volume 65:Supplement 1(2022)
• Page Start: S157
• Page End: S158
• Publication Date: 2022-06-01
• Subjects: LOBD -- EOBD -- bipolar disorder -- temperament; Psychiatry -- Periodicals; Mental illness -- Periodicals; Electronic journals; 616.89
• DOI: 10.1192/j.eurpsy.2022.422
• Languages: English
• ISSNs: 0924-9338

Abstract

Abstract : Introduction: Age at onset of type-I bipolar disorder (BD-I) typically averages 12-24 years, is older among patients with type-II-BD (BD-II), even though generally before 50-years-old (EOBD). Clinical observation of late-onset BD (LOBD) posed some questions regarding a differential phenotypic/psychopathological manifestations and affective temperaments between LOBD vs EOBD. Objectives: A case-control pilot-study was carried out to investigate psychopathological, clinical and temperamental features of a psychogeriatric cohort of LOBD and EOBD subjects. Methods: Out of 74 enrolled patients, 64 patients (31 EOBD, 33 LOBD) were included and administered an ad hoc socio-demographic datasheet, BPRS, CGI, GAF, HAM-D, GDS, MSRS, MRS, MOCA and TEMPS-M. Results: LOBD is significantly associated with higher rates of BD-II diagnosis (X2 = 26.1, p<.001), depressive (p=0.05) and mixed states (p=0.011), higher comorbid anxiety levels and depressive affective temperament (p<.001); while clinical manifestations of geriatric EOBD is significantly associated with higher endocrinological (X2 = 7.815, p=.005) and metabolic comorbidity (X2 = 6.896, p=.009), a diagnosis of BD-I, manic episodes and hyperthymic (p=.001) affective temperaments. GDS and MSRS total scores were significantly higher in LOBD (respectively, p<.001 and p=.008). Conclusions: Further studies with larger sample sizes and a control group should verify whether LOBD is a distinct psychopathological entity from EOBD and evaluate differences (if any) in terms of prognosis and treatment between EOBD and LOBD. Disclosure: No significant relationships.