The interplay of cardiac dysfunctions and hemodynamic impairments during the progression of myocardial infarction in male rats. (September 2022)

• Record Type: Journal Article
• Authors: Wang, Xuan; Li, Li; Zhao, Yiyang; Tan, Wenchang; Huo, Yunlong
• Is Part Of: Journal of biomechanics. Volume 142(2022)
• Publication Date: 2022-09
• Subjects: Myocardial infarction -- Cardiac mechanics -- Hemodynamics -- Windkessel model; HF Heart Failure -- HFrEF Heart failure with reduced ejection fraction -- LV Left ventricle -- MI Myocardial infarction -- STE Speckle tracking echocardiography -- CO Cardiac output -- SV Stroke volume -- EF Ejection fraction -- LVIDs LV internal diameter in systole -- LVIDd LV internal diameter in diastole -- ESV End-systolic volume -- EDV End-diastolic volume -- LVAWs LV anterior wall thickness in systole -- LVAWd LV anterior wall thickness in diastole -- LVSP LV systole pressure -- LVEDP LV end-diastole pressure -- AA Abdominal aorta -- CA Carotid artery -- FA Femoral artery -- PWV Pulse wave velocity -- SBP Systolic blood pressure -- DBP Diastolic blood pressure -- R Resistance -- C Compliance -- VSMC Vascular smooth muscle cell -- AIx Augmentation index -- FW Free wall -- IVS Interventricular septum -- ENDO Endocardium -- EPI Epicardium -- SVR Systemic vascular resistance; Animal mechanics -- Periodicals; Biomechanics -- Periodicals; Biomechanics -- Periodicals; Mécanique animale -- Périodiques; Biomécanique -- Périodiques; Electronic journals; 571.4305
• DOI: 10.1016/j.jbiomech.2022.111237
• Languages: English
• ISSNs: 0021-9290

Abstract

Abstract: Myocardial infarction (MI) can induce heart failure with reduced ejection fraction (HFrEF). Systemic circulation is of importance to interact with MI-induced HFrEF. Hence, we studied the changes of myofiber stresses and peripheral hemodynamics during the progression from MI to HFrEF. MI was induced in Wistar male rats by the coronary artery ligation surgery. Physiological and hemodynamic measurements were carried out in the LV and peripheral arteries at postoperative 3 and 6 weeks, based on which LV myofiber stresses were computed and peripheral hemodynamic analysis was demonstrated. This study showed that MI significantly impaired cardiac functions and peripheral hemodynamics and altered the corresponding histological properties of cardiac wall and peripheral arterial wall, which deteriorated with time after operation. In summary, the interplay of cardiac dysfunctions and hemodynamic impairments accelerates the progression of MI-induced HF.