Unraveling the interplay between iron homeostasis, ferroptosis and extramedullary hematopoiesis. (September 2022)

• Record Type: Journal Article
• Authors: Fernández-García, Victoria; González-Ramos, Silvia; Martín-Sanz, Paloma; Castrillo, Antonio; Boscá, Lisardo
• Is Part Of: Pharmacological research. Volume 183(2022)
• Publication Date: 2022-09
• Subjects: Erastin -- RSL3 -- Artesunate -- Amlodipine -- Nifedipine -- Quercetin -- Deferasirox -- Deferoxamine -- Dexrazoxane -- Doxorubicin; Iron -- Ferroptosis -- Ferritinophagy -- Extramedullary hematopoiesis -- Inflammation -- Metabolic syndrome -- Cancer; Pharmacology -- Periodicals; Pharmacology -- Periodicals; Research -- Periodicals; Médicaments -- Recherche -- Périodiques; Pharmacologie -- Périodiques; 615.105
• DOI: 10.1016/j.phrs.2022.106386
• Languages: English
• ISSNs: 1043-6618

Abstract

Abstract: Iron participates in myriad processes necessary to sustain life. During the past decades, great efforts have been made to understand iron regulation and function in health and disease. Indeed, iron is associated with both physiological (e.g., immune cell biology and function and hematopoiesis) and pathological (e.g., inflammatory and infectious diseases, ferroptosis and ferritinophagy) processes, yet few studies have addressed the potential functional link between iron, the aforementioned processes and extramedullary hematopoiesis, despite the obvious benefits that this could bring to clinical practice. Further investigation in this direction will shape the future development of individualized treatments for iron-linked diseases and chronic inflammatory disorders, including extramedullary hematopoiesis, metabolic syndrome, cardiovascular diseases and cancer. Graphical Abstract: Ferroptosis and bioavailability of iron in the context of hematopoiesis. Iron participates in both physiological and pathological processes. Excess iron produces cell toxicity, release of reactive oxygen species (ROS), cell damage, and triggers ferroptotic cell death. Iron overload impairs bone marrow (BM) function and hematopoiesis, and favors extramedullary hematopoiesis (EMH) in other peripheral immune tissues such as the spleen. Ferroptosis is mainly characterized by the accumulation of iron, lipid peroxidation, and non-apoptotic cell death. Molecules derived from ferroptosis, such as damage-associated molecular patterns (DAMP), feedback the processes of EMH. ga1