COVID-19 imparted immune manifestation can be combated by NLGP: Lessons from cancer research. (October 2022)

• Record Type: Journal Article
• Authors: Bose, Anamika; Baral, Rathindranath
• Is Part Of: Cytokine. Volume 158(2022)
• Publication Date: 2022-10
• Subjects: COVID-19 -- Cancer -- CD8+ T Cells -- NLGP -- Dendritic Cells -- IL-6; Cytokines -- Periodicals; 571.844
• DOI: 10.1016/j.cyto.2022.155980
• Languages: English
• ISSNs: 1043-4666

Abstract

Abstract: SARS-CoV-2 easily infects human monocytes, macrophages and possibly dendritic cells (DCs), causing dysfunctions of these important antigen presenting cells (APCs). Observed DC dysfunctions facilitate improper antigen presentation, which obviously results T cell anergy, exhaustion and apoptosis, thus, may be contributing significantly in SARS-CoV-2 infection associated lymphopenia. Neem Leaf Glycoprotein or NLGP has enormous role in altered DC functions, thereby, offering optimum T cell mediated cytotoxicity, as experienced from cancer system. Such NLGP guided correction of altered DCs might also be effective to generate proper SARS-CoV-2-specific effector and central memory T cells.