Toxicological profile, phytochemical analysis and anti-inflammatory properties of leaves of Vitex doniana Sweet. (Verbenaceae). Issue 8 (August 2022)

• Record Type: Journal Article
• Authors: Barry, Poussian Raymond; Sanou, Abdoudramane; Konaté, Kiessoun; Aworet-Samseny, Raïssa RR.; Sytar, Oksana; Dicko, Mamoudou Hama
• Is Part Of: Heliyon. Volume 8:Issue 8(2022)
• Publication Date: 2022-08
• Subjects: Vitex doniana Sweet -- Anti-inflammatory activities -- Acute toxicity -- Subachronic toxicity -- Bioactive coumpounds; Research -- Periodicals; Medical sciences -- Periodicals; Natural history -- Periodicals; Social sciences -- Periodicals; Earth sciences -- Periodicals; Physical sciences -- Periodicals; 507.2
• DOI: 10.1016/j.heliyon.2022.e10080
• Languages: English
• ISSNs: 2405-8440

Abstract

Abstract: Background: Natural herbal compounds are a source and alternative for new compounds with anti-inflammatory properties. Therefore, in-depth studies should be carried out to assess their safety and efficacy in order to avoid or prevent toxicological risks of these natural plant-based substances. V. doniana is a species of food plant used for the treatment of inflammatory diseases in Burkina Faso. This study aimed to estimate the anti-inflammatory properties in vitro and in vivo of the ethyl acetate fraction of the leaves of V. doniana . Methods: To do this, acute toxicity was first evaluated on the animal model. Biological activities (carrageenan test, formalin and xylene induced oedemas) were used to assess the anti-inflammatory power. Results: Regarding the dietary toxicology of the extracts, visual and clinical signs showed that the extracts are not at the end of the 15-day (acute toxicity) and 45-day (subacute toxicity) tests. In terms of anti-inflammatory activity in vivo, it was observed that the bioactive fraction (50, 100 and 200 mg/kg.b.w) had effective neurogenic anti-inflammatory properties. All of these effects observed were all dose-dependent. Conclusion: The results of this present research have proven that V. donania extracts can be used as anti-inflammatories.