Emerging role of astrocytes in oxytocin-mediated control of neural circuits and brain functions. (October 2022)

• Record Type: Journal Article
• Authors: Baudon, Angel; Clauss Creusot, Etienne; Althammer, Ferdinand; Schaaf, Christian P.; Charlet, Alexandre
• Is Part Of: Progress in neurobiology. Volume 217(2022)
• Publication Date: 2022-10
• Subjects: Astrocytes -- Oxytocin -- Amygdala -- Hypothalamus -- Neuropeptide; Neurobiology -- Periodicals; Neurology -- Periodicals; Neurology -- Periodicals; Neurobiologie -- Périodiques; 612.8
• DOI: 10.1016/j.pneurobio.2022.102328
• Languages: English
• ISSNs: 0301-0082

Abstract

Abstract: The neuropeptide oxytocin has been in the focus of scientists for decades due to its profound and pleiotropic effects on physiology, activity of neuronal circuits and behaviors, among which sociality. Until recently, it was believed that oxytocinergic action exclusively occurs through direct activation of neuronal oxytocin receptors. However, several studies demonstrated the existence and functional relevance of astroglial oxytocin receptors in various brain regions in the mouse and rat brain. Astrocytic signaling and activity is critical for many important physiological processes including metabolism, neurotransmitter clearance from the synaptic cleft and integrated brain functions. While it can be speculated that oxytocinergic action on astrocytes predominantly facilitates neuromodulation via the release of specific gliotransmitters, the precise role of astrocytic oxytocin receptors remains elusive. In this review, we discuss the latest studies on the interaction between the oxytocinergic system and astrocytes, including detailed information about intracellular cascades, and speculate about future research directions on astrocytic oxytocin signaling. Highlights: Astrocytes are emerging actors of the oxytocin functions. Subpopulations of astrocytes express functional oxytocin receptor. Oxytocin induces astrocytes morphological changes and astrocytes-mediated modulation of neuronal network activity. We propose several research directions to assess the role of astrocyte-neuron networks in oxytocin functions.