U-shaped association between abnormal serum uric acid levels and COVID-19 severity: reports from the Japan COVID-19 Task Force. (September 2022)

• Record Type: Journal Article
• Authors: Fukushima, Takahiro; Chubachi, Shotaro; Namkoong, Ho; Otake, Shiro; Nakagawara, Kensuke; Tanaka, Hiromu; Lee, Ho; Morita, Atsuho; Watase, Mayuko; Kusumoto, Tatsuya; Masaki, Katsunori; Kamata, Hirofumi; Ishii, Makoto; Hasegawa, Naoki; Harada, Norihiro; Ueda, Tetsuya; Ueda, Soichiro; Ishiguro, Takashi; Arimura, Ken; Saito, Fukuki; Yoshiyama, Takashi; Nakano, Yasushi; Mutoh, Yoshikazu; Suzuki, Yusuke; Murakami, Koji; Okada, Yukinori; Koike, Ryuji; Kitagawa, Yuko; Kimura, Akinori; Imoto, Seiya; Miyano, Satoru; Ogawa, Seishi; Kanai, Takanori; Fukunaga, Koichi;
• Is Part Of: International journal of infectious diseases. Volume 122(2022)
• Page Start: 747
• Page End: 754
• Publication Date: 2022-09
• Subjects: COVID-19 -- Hyperuricemia -- Hypouricemia -- High serum uric acid -- Low serum uric acid -- Respiratory care -- Severity; Communicable diseases -- Periodicals; Communicable Diseases -- Periodicals; Communicable diseases; Periodicals; Electronic journals; 616.9
• DOI: 10.1016/j.ijid.2022.07.014
• Languages: English
• ISSNs: 1201-9712

Abstract

Highlights: We analyzed the serum uric acid levels and hyperuricemia in patients with COVID-19. High serum uric acid levels were associated with the requirement of invasive mechanical ventilation. Low serum uric acid levels were also associated with the requirement of invasive mechanical ventilation. Abstract: Objectives: This study aimed to identify the relationship between abnormal serum uric acid levels or a history of hyperuricemia and COVID-19 severity in the Japanese population. Methods: We included 1523 patients enrolled in the Japan COVID-19 Task Force cohort between February 2020 and May 2021. We compared the clinical characteristics, including co-morbidities, laboratory findings, and outcomes, particularly invasive mechanical ventilation (IMV), among patients with and without abnormal uric acid levels or a history of hyperuricemia. Results: Patients with high serum uric acid levels were older and had higher body weight and body mass index than those without. In addition, the multiple logistic regression analysis revealed a significant association between high serum uric acid levels or a history of hyperuricemia and an increased risk of IMV (odds ratio [OR] = 1.77; P = 0.03/OR = 1.56; P = 0.04). Moreover, patients with low uric acid levels on admission were also associated significantly with the requirement of IMV (OR = 5.09; P <0.0001). Conclusion: Abnormal serum uric acid levels or a history of hyperuricemia were significantly associated with COVID-19 severity in the Japanese cohort.