Investigation of an Enterobacter hormaechei OXA-436 carbapenemase outbreak: when everything goes down the drain. Issue 3 (September 2022)

• Record Type: Journal Article
• Authors: Raun-Petersen, Christina; Toft, Annette; Nordestgaard, Mette Marie; Holm, Anette; Overballe-Petersen, Søren; Hammerum, Anette M.; Hasman, Henrik; Justesen, Ulrik Stenz
• Is Part Of: Infection Prevention in Practice. Volume 4:Issue 3(2022)
• Publication Date: 2022-09
• Subjects: Carbapenemase producing organisms -- Enterobacter hormaechei -- Environmental transmission -- Whole genome sequencing; Infection -- Prevention -- Periodicals; Infection Control; Infection -- Prevention; Electronic journals; Periodical; Electronic journals; Periodicals; 616.9045
• DOI: 10.1016/j.infpip.2022.100228
• Languages: English
• ISSNs: 2590-0889

Abstract

Summary: Over a time period of 18 months an Enterobacter hormaechei sequence type (ST) 90, harboring a bla OXA-436 carbapenemase gene, was isolated from seven patients at Odense University Hospital, Denmark. The patients were all from the same department, but there was no apparent direct epidemiological link. Whole genome sequencing (WGS) was performed on all clinical isolates as well as on a number of environmental samples including two E. hormaechei ST90 isolates carrying the bla OXA-436 gene, which were isolated in samples from two shower drains at the department. These drains were suspected to be the source of the outbreak.