Indole-diterpenes alkaloid profiles of native grasses involved in tremorgenic syndromes in the Argentine Patagonia. (15th October 2022)

• Record Type: Journal Article
• Authors: Zabaleta, Gabriela; Lee, Stephen T.; Cook, Daniel; Aguilar, Marcelo; Iannone, Leopoldo J.; Robles, Carlos; Martinez, Agustin
• Is Part Of: Toxicon. Volume 217(2022)
• Page Start: 107
• Page End: 111
• Publication Date: 2022-10-15
• Subjects: Tremorgenic syndrome -- Livestock -- Pooideae -- Endophytes -- Indole-diterpene alkaloid; Toxins -- Periodicals; Venom -- Periodicals; 615.9
• DOI: 10.1016/j.toxicon.2022.08.001
• Languages: English
• ISSNs: 0041-0101

Abstract

Abstract: One of the main intoxications to livestock in the Patagonia region of Argentina is the tremorgenic disease "Mal de Huecú", attributed to the consumption of the native grasses Poa huecu and/or Festuca argentina . In this report, five outbreaks of spontaneous intoxications were investigated. Several indole-diterpene alkaloids were identified in Poa huecu and Festuca argentina including the known tremorgen terpendole C and are likely the cause of "Mal de Huecú" disease. Graphical abstract: Image 1 Highlights: Poa huecu and Festuca argentina cause the tremorgenic syndrome known as Mal de Huecú. An Epichloë -like fungal endophyte was detected in both plants. Tremorgenic indole-diterpene alkaloids were detected in Poa huecu and Festuca argentina.