Isopropylpyrone and Phenylpyrones from the Leaves of Hypericum monogynum. Issue 7 (19th February 2020)

• Record Type: Journal Article
• Authors: Li, Ying‐Ying; Zhang, Yu−Bo; Li, Wen; Wu, Zhong‐Nan; Chen, Neng‐Hua; Wang, Guo‐Cai; Li, Yao‐Lan
• Is Part Of: ChemistrySelect. Volume 5:Issue 7(2020)
• Page Start: 2317
• Page End: 2321
• Publication Date: 2020-02-19
• Subjects: absolute configuration -- cytotoxicity activity -- enantiomer -- Hypericum monogynum -- pyranones derivative; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.201903815
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: A new isopropylpyrone, hypemonone F (1 ), and a new phenylpyrone, hypemonone G (2 ), along with five known phenylpyrones, peplidiforone B (3 ), hypemonone C (4 ), hypemonone B (5 ), 3‐(1, 1‐dimethyl‐2‐propen‐1‐yl)‐4‐methoxy‐6‐phenyl‐2H‐pyran‐2‐one (6 ), hyperenone A (7 ) were isolated from the leaves of Hypericum monogynum . Their structures were identified on the basis of the spectral data (IR, UV, HRESIMS, and NMR). The absolute configurations of 1 −4 were determined by electronic circular dichroism and single crystal X‐ray analyses. All isolated compounds (1 −7 ) were evaluated for their cytotoxic activities on tumor cells (HeLa and HepG2). Compounds 1 −7 showed cytotoxic activities against HeLa cells with IC50 values of 28.27 ± 2.65 to 89.02 ± 2.30 μM, and compounds 2, 3, 6, 7 showed cytotoxic activities against HepG2 cells with IC50 values of 68.44 ± 1.45 to 80.7 ± 1.66 μM. Abstract : A new isopropylpyrone, (±)‐hypemonone F, and a new phenylpyrone, (±)‐hypemonone G, along with five known phenylpyrone derivatives were isolated from the leaves of Hypericum monogynum . In addition, all isolated compounds were evaluated for their cytotoxic activities on tumor cells (HeLa and HepG2).