An appraisal of vascular endothelial growth factor (VEGF): the dynamic molecule of wound healing and its current clinical applications. (3rd September 2022)

• Record Type: Journal Article
• Authors: Goswami, Aakansha Giri; Basu, Somprakas; Huda, Farhanul; Pant, Jayanti; Ghosh Kar, Amrita; Banerjee, Tuhina; Shukla, Vijay Kumar
• Is Part Of: Growth factors. Volume 40:Number 3/4(2022)
• Page Start: 73
• Page End: 88
• Publication Date: 2022-09-03
• Subjects: Vascular endothelial growth factor -- wound healing -- angiogenesis -- diabetic ulcer -- venous ulcer -- peripheral arterial disease; Growth factors -- Periodicals; Physiology -- Periodicals; 611
• DOI: 10.1080/08977194.2022.2074843
• Languages: English
• ISSNs: 0897-7194

Abstract

Abstract: Angiogenesis is a critical step of wound healing, and its failure leads to chronic wounds. The idea of restoring blood flow to the damaged tissues by promoting neo-angiogenesis is lucrative and has been researched extensively. Vascular endothelial growth factor (VEGF), a key dynamic molecule of angiogenesis has been investigated for its functions. In this review, we aim to appraise its biology, the comprehensive role of this dynamic molecule in the wound healing process, and how this knowledge has been translated in clinical application in various types of wounds. Although, most laboratory research on the use of VEGF is promising, its clinical applications have not met great expectations. We discuss various lacunae that might exist in making its clinical application unsuccessful for commercial use, and provide insight to the foundation for future research.