Atypical macroglossia caused by multiple myeloma‐associated systemic amyloidosis with severe lingual movement disorder and tongue sclerosis. Issue 1 (11th December 2020)

• Record Type: Journal Article
• Authors: Murakami, Yumi; Watanabe, Genya; Yuki, Tsubasa; Sugaya, Ryo; Harigae, Souske; Nakamura, Takaaki; Kawasaki, Emiko; Tsukita, Kenichi; Watanabe, Mai; Harashima, Shogo; Suzuki, Hiroyoshi; Suzuki, Yasushi
• Other Names: Taniwaki Takayuki guestEditor.
• Is Part Of: Neurology and clinical neuroscience. Volume 9:Issue 1(2021)
• Page Start: 127
• Page End: 129
• Publication Date: 2020-12-11
• Subjects: amyloidosis -- amyotrophic lateral sclerosis -- macroglossia -- multiple myeloma -- needle electromyogram; Neurology -- Periodicals; Neurosciences -- Periodicals; 616.8
• DOI: 10.1111/ncn3.12464
• Languages: English
• ISSNs: 2049-4173

Abstract

Abstract: A 70‐year‐old man presented with dysphagia and difficulty in moving the tongue. Macroscopic findings showed features resembling mild tongue atrophy. We suspected a neurodegenerative disease which causes tongue atrophy such as amyotrophic lateral sclerosis. A needle electromyogram showed a strong resistance from the tongue owing to its hardness. Detection of Bence Jones protein κ type M protein in the serum led to a diagnosis of multiple myeloma‐associated light‐chain (κ) type amyloidosis. Thus, in patients with a rugose‐textured and uneven tongue mimicking atrophy, macroglossia caused by amyloidosis should be considered by examining the tongue hardness.