Magnesium deficiency and febrile seizure: A systematic review and meta‐analysis. Issue 5 (7th June 2020)

• Record Type: Journal Article
• Authors: Ataei‐Nakhaei, Alireza; Rouhani, Zahra‐Sadat; Bakhtiari, Elham
• Is Part Of: Neurology and clinical neuroscience. Volume 8:Issue 5(2020:Sep.)
• Page Start: 225
• Page End: 231
• Publication Date: 2020-06-07
• Subjects: child -- magnesium -- seizure disorder; Neurology -- Periodicals; Neurosciences -- Periodicals; 616.8
• DOI: 10.1111/ncn3.12410
• Languages: English
• ISSNs: 2049-4173

Abstract

Abstract: There are inconsistent data reporting magnesium is low in children with febrile seizure compared with febrile cases. Present systematic review was performed comparing the serum level of magnesium in febrile children aged 6‐72 months with and without seizure. A systematic search was performed in the relevant databases up to August 2019. Papers comparing the serum level of magnesium in febrile children with and without seizure were selected. The major outcome was serum level of magnesium. Random effect model was used to calculate the pooled standardized mean difference with 95% confidence intervals. Totally 10 papers were included. According to meta‐analysis, the serum level of magnesium significantly is lower in children with febrile seizure versus febrile ones (standardized mean difference: −0.85, 95% confidence interval = (−1.31, −0.39). According to sensitivity analysis, no significant change was observed in pooled standardized mean difference. In meta‐regression demographic characteristics matching, sample size and method of magnesium measurement showed a significant effect on between‐study variance ( P = .001). Present systematic review confirmed a significant relationship between hypomagnesemia and seizure in febrile children aged 6‐72 months. It has been purposed that decreased level of magnesium may play a role in the pathogenesis of seizure in febrile children.