An exploratory study on the association of lifestyle factors with serum etonogestrel concentrations among contraceptive implant users. (4th July 2021)

• Record Type: Journal Article
• Authors: Lazorwitz, Aaron; Sheeder, Jeanelle; Teal, Stephanie
• Is Part Of: European journal of contraception & reproductive health care. Volume 26:Number 4(2021)
• Page Start: 323
• Page End: 325
• Publication Date: 2021-07-04
• Subjects: Lifestyle -- contraceptive implant -- etonogestrel -- diet -- exercise -- pharmacokinetics; Contraception -- Periodicals; Reproductive health -- Periodicals; Generative organs, Female -- Periodicals; Contraception -- Periodicals; Reproductive Medicine -- Periodicals; 613.9
• DOI: 10.1080/13625187.2021.1887475
• Languages: English
• ISSNs: 1362-5187

Abstract

Abstract: Purpose: To explore how diet and exercise habits associate with serum etonogestrel concentrations among contraceptive implant users. Materials and methods: We conducted a secondary analysis of healthy, reproductive-age women using etonogestrel implants. This study was registered on ClinicalTrials.gov, NCT03092037. We assessed diet and exercise habits with two validated surveys: Healthy Eating Vital Signs and the Stanford Brief Activity Survey. Participants previously had their serum etonogestrel concentrations measured using a validated liquid-chromatography mass-spectrometry assay. We then used linear modelling to test for associations between survey responses and serum etonogestrel concentrations. Results: Among 129 participants, diet and exercise habits had no significant associations with serum etonogestrel concentrations ( p = 0.22–0.72), with inconsistent effects found for increased caloric intake and sedentary lifestyle. Conclusion: This exploratory study found no significant effect of diet or exercise habits on steady-state pharmacokinetics among contraceptive implant users. Clinical Trial Registration: Clinicaltrials.gov: NCT03092037