Use of Drug-level Testing and Single-genome Sequencing to Unravel a Case of Human Immunodeficiency Virus Seroconversion on Pre-exposure Prophylaxis. (20th July 2020)

• Record Type: Journal Article
• Authors: Spinelli, Matthew A; Lowery, Brentton; Shuford, Jennifer A; Spindler, Jon; Kearney, Mary F; McFarlane, Jenny R; McDonald, Cheryl; Okochi, Hideaki; Phung, Nhi; Kuncze, Karen; Jee, Kathryn; Johannessen, DeeJay; Anderson, Peter L; Smith, Dawn K; Defechereux, Patricia; Grant, Robert M; Gandhi, Monica
• Is Part Of: Clinical infectious diseases. Volume 72:Number 11(2021)
• Page Start: 2025
• Page End: 2028
• Publication Date: 2020-07-20
• Subjects: PrEP -- HIV seroconversion -- adherence -- single-genome-sequencing -- PrEP failure; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciaa1011
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: Cases of seroconversion on pre-exposure prophylaxis (PrEP) should be carefully investigated, given their public health implications and rarity. We report a case of transmitted drug resistance causing seroconversion on PrEP in spite of high adherence, confirmed with dried blood spot and segmental hair drug-level testing and single-genome sequencing.